Remote Psychophysical Evaluation of Olfactory and Gustatory Functions in Early-stage Coronavirus Disease 2019 Patients: the Bologna Experience of 300 Cases

Overview

Journal J Laryngol Otol

Publisher Cambridge University Press

Specialty Otorhinolaryngology

Date 2020 Jul 2

PMID 32605666

Citations 46

Authors

M Petrocelli

F Ruggiero

A M Baietti

P Pandolfi

G Salzano

F A Salzano

J R Lechien

S Saussez

G De Riu

L A Vaira

Affiliations

Soon will be listed here.

Abstract

Background: An objective evaluation of coronavirus disease 2019 in the first days of infection is almost impossible, as affected individuals are generally in home quarantine, and there is limited accessibility for the operator who should perform the test. To overcome this limitation, a recently validated psychophysical self-administered test was used, which can be performed remotely in the assessment of early-stage coronavirus disease 2019 patients.

Methods: Olfactory and gustatory functions were objectively assessed in 300 patients in the first 7 days from coronavirus disease 2019 symptom onset.

Results: Seventy per cent of the patients presented olfactory and/or gustatory disorders. The dysfunctions detected were mainly complete anosmia (47 per cent) or ageusia (38 per cent). A significant correlation was found between taste dysfunction and female gender (odds ratio = 1.936, p = 0.014) and fever (odds ratio = 2.132, p = 0.003).

Conclusion: The psychophysical evaluation protocol proposed is an effective tool for the fast and objective evaluation of patients in the early stages of coronavirus disease 2019. Chemosensitive disorders have been confirmed to be frequent and early symptoms of the coronavirus infection, and, in a significant number of cases, they are the first or only manifestation of coronavirus disease 2019.

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References

Vaira L, Deiana G, Fois A, Pirina P, Madeddu G, De Vito A . Objective evaluation of anosmia and ageusia in COVID-19 patients: Single-center experience on 72 cases. Head Neck. 2020; 42(6):1252-1258. PMC: 7267244. DOI: 10.1002/hed.26204. View

Russell B, Moss C, Rigg A, Hopkins C, Papa S, Van Hemelrijck M . Anosmia and ageusia are emerging as symptoms in patients with COVID-19: What does the current evidence say?. Ecancermedicalscience. 2020; 14:ed98. PMC: 7134577. DOI: 10.3332/ecancer.2020.ed98. View

Spinato G, Fabbris C, Polesel J, Cazzador D, Borsetto D, Hopkins C . Alterations in Smell or Taste in Mildly Symptomatic Outpatients With SARS-CoV-2 Infection. JAMA. 2020; 323(20):2089-2090. PMC: 7177631. DOI: 10.1001/jama.2020.6771. View

Hopkins C, Surda P, Kumar N . Presentation of new onset anosmia during the COVID-19 pandemic. Rhinology. 2020; 58(3):295-298. DOI: 10.4193/Rhin20.116. View

Vaira L, Salzano G, Deiana G, Salzano F, De Riu G . In Response to: In Reference to Anosmia and Ageusia: Common Findings in COVID-19 Patients. Laryngoscope. 2020; 130(9):E506. PMC: 7361620. DOI: 10.1002/lary.28837. View

Moein S, Hashemian S, Mansourafshar B, Khorram-Tousi A, Tabarsi P, Doty R . Smell dysfunction: a biomarker for COVID-19. Int Forum Allergy Rhinol. 2020; 10(8):944-950. PMC: 7262123. DOI: 10.1002/alr.22587. View

Karimi-Galougahi M, Raad N, Mikaniki N . Anosmia and the Need for COVID-19 Screening during the Pandemic. Otolaryngol Head Neck Surg. 2020; 163(1):96-97. DOI: 10.1177/0194599820925056. View

Vaira L, Salzano G, Petrocelli M, Deiana G, Salzano F, De Riu G . Validation of a self-administered olfactory and gustatory test for the remotely evaluation of COVID-19 patients in home quarantine. Head Neck. 2020; 42(7):1570-1576. PMC: 7267597. DOI: 10.1002/hed.26228. View

Vaira L, Hopkins C, Salzano G, Petrocelli M, Melis A, Cucurullo M . Olfactory and gustatory function impairment in COVID-19 patients: Italian objective multicenter-study. Head Neck. 2020; 42(7):1560-1569. PMC: 7280583. DOI: 10.1002/hed.26269. View

10.

Xydakis M, Dehgani-Mobaraki P, Holbrook E, Geisthoff U, Bauer C, Hautefort C . Smell and taste dysfunction in patients with COVID-19. Lancet Infect Dis. 2020; 20(9):1015-1016. PMC: 7159875. DOI: 10.1016/S1473-3099(20)30293-0. View

11.

Sedaghat A, Gengler I, Speth M . Olfactory Dysfunction: A Highly Prevalent Symptom of COVID-19 With Public Health Significance. Otolaryngol Head Neck Surg. 2020; 163(1):12-15. DOI: 10.1177/0194599820926464. View

12.

Yan C, Faraji F, DeConde A . Reply to: Self-reported olfactory loss in COVID-19: is it really a favorable prognostic factor?. Int Forum Allergy Rhinol. 2020; 10(7):927-928. PMC: 7272966. DOI: 10.1002/alr.22606. View

13.

Lechien J, Cabaraux P, Chiesa-Estomba C, Khalife M, Hans S, Calvo-Henriquez C . Objective olfactory evaluation of self-reported loss of smell in a case series of 86 COVID-19 patients. Head Neck. 2020; 42(7):1583-1590. PMC: 7280665. DOI: 10.1002/hed.26279. View

14.

Lechien J, Chiesa-Estomba C, De Siati D, Horoi M, Le Bon S, Rodriguez A . Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. Eur Arch Otorhinolaryngol. 2020; 277(8):2251-2261. PMC: 7134551. DOI: 10.1007/s00405-020-05965-1. View

15.

Vaira L, Salzano G, De Riu G . The importance of olfactory and gustatory disorders as early symptoms of coronavirus disease (COVID-19). Br J Oral Maxillofac Surg. 2020; 58(5):615-616. PMC: 7184007. DOI: 10.1016/j.bjoms.2020.04.024. View

16.

Vaira L, Salzano G, Fois A, Piombino P, De Riu G . Potential pathogenesis of ageusia and anosmia in COVID-19 patients. Int Forum Allergy Rhinol. 2020; 10(9):1103-1104. PMC: 7267531. DOI: 10.1002/alr.22593. View

17.

Vaira L, Salzano G, Deiana G, De Riu G . Anosmia and Ageusia: Common Findings in COVID-19 Patients. Laryngoscope. 2020; 130(7):1787. PMC: 7228304. DOI: 10.1002/lary.28692. View

18.

Lechien J, Hopkins C, Saussez S . Sniffing out the evidence; It's now time for public health bodies recognize the link between COVID-19 and smell and taste disturbance. Rhinology. 2020; 58(4):402-403. DOI: 10.4193/Rhin20.159. View

19.

Vaira L, Salzano G, Deiana G, De Riu G . In Response to Isolated Anosmia and Ageusia in COVID-19 With Spontaneous Recovery. Laryngoscope. 2020; 130(9):E503. PMC: 7323015. DOI: 10.1002/lary.28836. View

20.

Vaira L, Salzano G, Deiana G, De Riu G . In Response to Anosmia and Ageusia: Common Findings in COVID-19 Patients. Laryngoscope. 2020; 130(11):E695. PMC: 7405289. DOI: 10.1002/lary.28753. View