Gonococcal Resistance Can Be Viewed Productively As Part of a Syndemic of Antimicrobial Resistance: an Ecological Analysis of 30 European Countries

Overview

Journal Antimicrob Resist Infect Control

Publisher Biomed Central

Specialty Infectious Diseases

Date 2020 Jul 2

PMID 32605597

Citations 5

Authors

Chris Kenyon

Sheeba S Manoharan-Basil

Christophe Van Dijck

Affiliations

Soon will be listed here.

Abstract

Background: It is unclear how important bystander selection is in the genesis of antimicrobial resistance (AMR) in Neisseria gonorrhoeae.

Methods: We assessed bystander selection in a novel way. Mixed-effects linear regression was used to assess if country-level prevalence of gonococcal AMR in 30 European countries predicts homologous AMR in other bacteria. The data used was from the European Antimicrobial Resistance Surveillance Network.

Results: The prevalence of gonococcal ciprofloxacin resistance was found to be positively associated with AMR prevalence in E. coli (coef. 0.52; P = 0.007), Acinetobacter spp. (coef. 0.13; P = 0.044) and Pseudomonas aeruginosa (coef. 0.36; P = 0.020) but not Klebsiella pneumoniae. Azithromycin resistance in N. gonorrhoeae was positively associated with macrolide resistance in Streptococcus pneumoniae (coef. 0.01; P = 0.018). No association was found for cephalosporins.

Conclusions: Gonococcal AMR is linked to that in other bacteria. This finding is likely explained by high antimicrobial consumption in affected populations and provides additional motivation for strengthening antimicrobial stewardship programs.

Citing Articles

Investigating the cause of increased tetracycline-resistant Neisseria gonorrhoeae in England, 2016-20.

Pitt-Kendall R, Sun S, Hughes S, Merrick R, Donaldson H, Rayment M J Antimicrob Chemother. 2024; 79(5):1060-1068.

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Antimicrobial Resistance in the Global Health Network: Known Unknowns and Challenges for Efficient Responses in the 21st Century.

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and Antimicrobial Resistance Among a Cohort of West African Men Who Have Sex With Men Using Preexposure Prophylaxis (CohMSM-PrEP ANRS 12369-Expertise France Study).

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Ciprofloxacin Concentrations 1/1000th the MIC Can Select for Antimicrobial Resistance in -Important Implications for Maximum Residue Limits in Food.

Gonzalez N, Abdellati S, De Baetselier I, Laumen J, Van Dijck C, de Block T Antibiotics (Basel). 2022; 11(10).

PMID: 36290088 PMC: 9598464. DOI: 10.3390/antibiotics11101430.

Choosing New Therapies for Gonorrhoea: We Need to Consider the Impact on the Pan- Genome. A Viewpoint.

Kenyon C, Laumen J, Manoharan-Basil S Antibiotics (Basel). 2021; 10(5).

PMID: 34062856 PMC: 8147325. DOI: 10.3390/antibiotics10050515.

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