Update on the Effects of Antioxidants on Diabetic Retinopathy: In Vitro Experiments, Animal Studies and Clinical Trials

Overview

Journal Antioxidants (Basel)

Date 2020 Jul 2

PMID 32604941

Citations 25

Authors

Jose Javier Garcia-Medina

Elena Rubio-Velazquez

Elisa Foulquie-Moreno

Ricardo P Casaroli-Marano

Maria Dolores Pinazo-Duran

Vicente Zanon-Moreno

Monica Del-Rio-Vellosillo

Affiliations

Soon will be listed here.

Abstract

Current therapies for diabetic retinopathy (DR) incorporate blood glucose and blood pressure control, vitrectomy, photocoagulation, and intravitreal injections of anti-vascular endothelial growth factors or corticosteroids. Nonetheless, these techniques have not been demonstrated to completely stop the evolution of this disorder. The pathophysiology of DR is not fully known, but there is more and more evidence indicating that oxidative stress is an important mechanism in the progression of DR. In this sense, antioxidants have been suggested as a possible therapy to reduce the complications of DR. In this review we aim to assemble updated information in relation to in vitro experiments, animal studies and clinical trials dealing with the effect of the antioxidants on DR.

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References

Madsen-Bouterse S, Zhong Q, Mohammad G, Ho Y, Kowluru R . Oxidative damage of mitochondrial DNA in diabetes and its protection by manganese superoxide dismutase. Free Radic Res. 2010; 44(3):313-21. PMC: 3025400. DOI: 10.3109/10715760903494168. View

Lin J, Bierhaus A, Bugert P, Dietrich N, Feng Y, vom Hagen F . Effect of R-(+)-alpha-lipoic acid on experimental diabetic retinopathy. Diabetologia. 2006; 49(5):1089-96. DOI: 10.1007/s00125-006-0174-y. View

Kusuhara S, Fukushima Y, Ogura S, Inoue N, Uemura A . Pathophysiology of Diabetic Retinopathy: The Old and the New. Diabetes Metab J. 2018; 42(5):364-376. PMC: 6202564. DOI: 10.4093/dmj.2018.0182. View

Shanab A, Nakazawa T, Ryu M, Tanaka Y, Himori N, Taguchi K . Metabolic stress response implicated in diabetic retinopathy: the role of calpain, and the therapeutic impact of calpain inhibitor. Neurobiol Dis. 2012; 48(3):556-67. DOI: 10.1016/j.nbd.2012.07.025. View

Kheirouri S, Naghizadeh S, Alizadeh M . Zinc supplementation does not influence serum levels of VEGF, BDNF, and NGF in diabetic retinopathy patients: a randomized controlled clinical trial. Nutr Neurosci. 2018; 22(10):718-724. DOI: 10.1080/1028415X.2018.1436236. View

Bogdanov P, Sola-Adell C, Hernandez C, Garcia-Ramirez M, Sampedro J, Simo-Servat O . Calcium dobesilate prevents the oxidative stress and inflammation induced by diabetes in the retina of db/db mice. J Diabetes Complications. 2017; 31(10):1481-1490. DOI: 10.1016/j.jdiacomp.2017.07.009. View

Feghhi M, Farrahi F, Abbaspour M, Takhtaeian A . Effect of adding oral calcium dobesilate to laser photocoagulation on the macular thickness in patients with diabetic macular edema: a randomized clinical trial. Adv Pharm Bull. 2014; 4(4):375-8. PMC: 4137428. DOI: 10.5681/apb.2014.055. View

Gong X, Draper C, Allison G, Marisiddaiah R, Rubin L . Effects of the Macular Carotenoid Lutein in Human Retinal Pigment Epithelial Cells. Antioxidants (Basel). 2017; 6(4). PMC: 5745510. DOI: 10.3390/antiox6040100. View

Di Leo M, Ghirlanda G, Gentiloni Silveri N, Giardina B, Franconi F, Santini S . Potential therapeutic effect of antioxidants in experimental diabetic retina: a comparison between chronic taurine and vitamin E plus selenium supplementations. Free Radic Res. 2003; 37(3):323-30. DOI: 10.1080/1071576021000055271. View

10.

Grover A, Samson S . Antioxidants and vision health: facts and fiction. Mol Cell Biochem. 2013; 388(1-2):173-83. DOI: 10.1007/s11010-013-1908-z. View

11.

Chous A, Richer S, Gerson J, Kowluru R . The Diabetes Visual Function Supplement Study (DiVFuSS). Br J Ophthalmol. 2015; 100(2):227-34. PMC: 4752618. DOI: 10.1136/bjophthalmol-2014-306534. View

12.

Liu L, Zuo Z, Lu S, Liu A, Liu X . Naringin attenuates diabetic retinopathy by inhibiting inflammation, oxidative stress and NF-κB activation and . Iran J Basic Med Sci. 2017; 20(7):813-821. PMC: 5569591. DOI: 10.22038/IJBMS.2017.9017. View

13.

Kowluru R, Odenbach S . Effect of long-term administration of alpha-lipoic acid on retinal capillary cell death and the development of retinopathy in diabetic rats. Diabetes. 2004; 53(12):3233-8. DOI: 10.2337/diabetes.53.12.3233. View

14.

Hu B, Hu Y, Lin S, Ma W, Li X . Application of Lutein and Zeaxanthin in nonproliferative diabetic retinopathy. Int J Ophthalmol. 2012; 4(3):303-6. PMC: 3340817. DOI: 10.3980/j.issn.2222-3959.2011.03.19. View

15.

Dong Y, Wan G, Yan P, Qian C, Li F, Peng G . Fabrication of resveratrol coated gold nanoparticles and investigation of their effect on diabetic retinopathy in streptozotocin induced diabetic rats. J Photochem Photobiol B. 2019; 195:51-57. DOI: 10.1016/j.jphotobiol.2019.04.012. View

16.

Zhang L, Zhang Z, Liang S . Epigallocatechin-3-gallate protects retinal vascular endothelial cells from high glucose stress in vitro via the MAPK/ERK-VEGF pathway. Genet Mol Res. 2016; 15(2). DOI: 10.4238/gmr.15027874. View

17.

Pfister F, Riedl E, Wang Q, Vom Hagen F, Deinzer M, Harmsen M . Oral carnosine supplementation prevents vascular damage in experimental diabetic retinopathy. Cell Physiol Biochem. 2011; 28(1):125-36. DOI: 10.1159/000331721. View

18.

Peddada K, Brown A, Verma V, Nebbioso M . Therapeutic potential of curcumin in major retinal pathologies. Int Ophthalmol. 2018; 39(3):725-734. DOI: 10.1007/s10792-018-0845-y. View

19.

Ung L, Pattamatta U, Carnt N, Wilkinson-Berka J, Liew G, White A . Oxidative stress and reactive oxygen species: a review of their role in ocular disease. Clin Sci (Lond). 2017; 131(24):2865-2883. DOI: 10.1042/CS20171246. View

20.

Laubertova L, Konarikova K, Gbelcova H, Durackova Z, Muchova J, Garaiova I . Fish oil emulsion supplementation might improve quality of life of diabetic patients due to its antioxidant and anti-inflammatory properties. Nutr Res. 2017; 46:49-58. DOI: 10.1016/j.nutres.2017.07.012. View