Association Between Prenatal Exposure to Household Pesticides and Neonatal Weight and Length Growth in the Japan Environment and Children's Study

Overview

Journal Int J Environ Res Public Health

Publisher MDPI

Specialties Environmental Health
Public Health

Date 2020 Jul 2

PMID 32604899

Citations 6

Authors

Taro Matsuki

Takeshi Ebara

Hazuki Tamada

Yuki Ito

Yasuyuki Yamada

Hirohisa Kano

Takahiro Kurihara

Hirotaka Sato

Sayaka Kato

Shinji Saitoh

Mayumi Sugiura-Ogasawara

Michihiro Kamijima

The Japan Environment And Childrens Study Jecs Group

Affiliations

Soon will be listed here.

Abstract

The effects of prenatal exposure to household pesticides on fetal and neonatal growth have not been fully clarified. The present study aims to determine the effects of prenatal exposure to pesticides on neonates' body size and growth during the first month. This study included 93,718 pairs of pregnant women and their children from the Japan Environment and Children's Study. Participants completed self-reporting questionnaires during their second or third trimesters on their demographic characteristics and frequency of pesticide use during pregnancy. Child weight, length, and sex were obtained from medical record transcripts. Birth weight and length, as well as weight and length changes over the first month, were estimated using an analysis of covariance. Frequency of exposure to almost all pesticides had no effects on birth weight and length. However, we found small but significant associations (i) between the use of fumigation insecticides and decreased birth weight, and (ii) between frequencies of exposure to pyrethroid pesticides, especially mosquito coils/mats, and suppression of neonatal length growth. Prenatal exposure to household pesticides, especially those containing pyrethroids, might adversely influence fetal and postnatal growth trajectories.

Citing Articles

Association between pre- and postnatal exposure to endocrine-disrupting chemicals and birth and neurodevelopmental outcomes: an extensive review.

Yesildemir O, Celik M Clin Exp Pediatr. 2023; 67(7):328-346.

PMID: 37986566 PMC: 11222910. DOI: 10.3345/cep.2023.00941.

Pyrethroid pesticide exposure and placental effects.

Wolfe J, Marsit C Mol Cell Endocrinol. 2023; 578:112070.

PMID: 37722502 PMC: 10591723. DOI: 10.1016/j.mce.2023.112070.

Associations of Prenatal Agricultural Farm Work with Fetal Overgrowth and Pregnancy Complications in State of Arizona Birth Records.

Parra K, Harris R, Farland L, Beamer P, Furlong M J Occup Environ Med. 2023; 65(8):635-642.

PMID: 37167931 PMC: 10523987. DOI: 10.1097/JOM.0000000000002877.

A narrative review of converging evidence addressing developmental toxicity of pyrethroid insecticides.

Elser B, Hing B, Stevens H Crit Rev Toxicol. 2022; 52(5):371-388.

PMID: 36345971 PMC: 9930199. DOI: 10.1080/10408444.2022.2122769.

Endocrine Disrupting Chemicals' Effects in Children: What We Know and What We Need to Learn?.

Predieri B, Iughetti L, Bernasconi S, Street M Int J Mol Sci. 2022; 23(19).

PMID: 36233201 PMC: 9570268. DOI: 10.3390/ijms231911899.

References

Wagner-Schuman M, Richardson J, Auinger P, Braun J, Lanphear B, Epstein J . Association of pyrethroid pesticide exposure with attention-deficit/hyperactivity disorder in a nationally representative sample of U.S. children. Environ Health. 2015; 14:44. PMC: 4458051. DOI: 10.1186/s12940-015-0030-y. View

Osaka A, Ueyama J, Kondo T, Nomura H, Sugiura Y, Saito I . Exposure characterization of three major insecticide lines in urine of young children in Japan-neonicotinoids, organophosphates, and pyrethroids. Environ Res. 2016; 147:89-96. DOI: 10.1016/j.envres.2016.01.028. View

Ding G, Cui C, Chen L, Gao Y, Zhou Y, Shi R . Prenatal exposure to pyrethroid insecticides and birth outcomes in Rural Northern China. J Expo Sci Environ Epidemiol. 2014; 25(3):264-70. DOI: 10.1038/jes.2014.86. View

Swale D, Bloomquist J . Is DEET a dangerous neurotoxicant?. Pest Manag Sci. 2019; 75(8):2068-2070. DOI: 10.1002/ps.5476. View

Crofton K, Craft E, Hedge J, Gennings C, Simmons J, Carchman R . Thyroid-hormone-disrupting chemicals: evidence for dose-dependent additivity or synergism. Environ Health Perspect. 2005; 113(11):1549-54. PMC: 1310917. DOI: 10.1289/ehp.8195. View

Twum C, Wei Y . The association between urinary concentrations of dichlorophenol pesticides and obesity in children. Rev Environ Health. 2011; 26(3):215-9. DOI: 10.1515/reveh.2011.029. View

Coker E, Chevrier J, Rauch S, Bradman A, Obida M, Crause M . Association between prenatal exposure to multiple insecticides and child body weight and body composition in the VHEMBE South African birth cohort. Environ Int. 2018; 113:122-132. PMC: 5866210. DOI: 10.1016/j.envint.2018.01.016. View

Iwai-Shimada M, Nakayama S, Isobe T, Michikawa T, Yamazaki S, Nitta H . Questionnaire results on exposure characteristics of pregnant women participating in the Japan Environment and Children Study (JECS). Environ Health Prev Med. 2018; 23(1):45. PMC: 6138908. DOI: 10.1186/s12199-018-0733-0. View

Barr D, Olsson A, Wong L, Udunka S, Baker S, Whitehead R . Urinary concentrations of metabolites of pyrethroid insecticides in the general U.S. population: National Health and Nutrition Examination Survey 1999-2002. Environ Health Perspect. 2010; 118(6):742-8. PMC: 2898848. DOI: 10.1289/ehp.0901275. View

10.

Suzuki K, Shinohara R, Sato M, Otawa S, Yamagata Z . Association Between Maternal Smoking During Pregnancy and Birth Weight: An Appropriately Adjusted Model From the Japan Environment and Children's Study. J Epidemiol. 2016; 26(7):371-7. PMC: 4919482. DOI: 10.2188/jea.JE20150185. View

11.

Hanke W, Romitti P, Fuortes L, Sobala W, Mikulski M . The use of pesticides in a Polish rural population and its effect on birth weight. Int Arch Occup Environ Health. 2003; 76(8):614-20. DOI: 10.1007/s00420-003-0471-4. View

12.

Dabrowski S, Hanke W, Polanska K, Makowiec-Dabrowska T, Sobala W . Pesticide exposure and birthweight: an epidemiological study in Central Poland. Int J Occup Med Environ Health. 2003; 16(1):31-9. View

13.

Vollmer B, Edmonds C . School Age Neurological and Cognitive Outcomes of Fetal Growth Retardation or Small for Gestational Age Birth Weight. Front Endocrinol (Lausanne). 2019; 10:186. PMC: 6447606. DOI: 10.3389/fendo.2019.00186. View

14.

Shafer T, Meyer D, Crofton K . Developmental neurotoxicity of pyrethroid insecticides: critical review and future research needs. Environ Health Perspect. 2005; 113(2):123-36. PMC: 1277854. DOI: 10.1289/ehp.7254. View

15.

Schoenig G, Fisher L, Hartnagel Jr R . Teratologic evaluations of N,N-diethyl-m-toluamide (DEET) in rats and rabbits. Fundam Appl Toxicol. 1994; 23(1):63-9. DOI: 10.1006/faat.1994.1079. View

16.

Chevrier J, Rauch S, Obida M, Crause M, Bornman R, Eskenazi B . Sex and poverty modify associations between maternal peripartum concentrations of DDT/E and pyrethroid metabolites and thyroid hormone levels in neonates participating in the VHEMBE study, South Africa. Environ Int. 2019; 131:104958. PMC: 6728182. DOI: 10.1016/j.envint.2019.104958. View

17.

Casida J, Quistad G . Golden age of insecticide research: past, present, or future?. Annu Rev Entomol. 1998; 43:1-16. DOI: 10.1146/annurev.ento.43.1.1. View

18.

McCoull W, Addie M, Birch A, Birtles S, Buckett L, Butlin R . Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes. Bioorg Med Chem Lett. 2012; 22(12):3873-8. DOI: 10.1016/j.bmcl.2012.04.117. View

19.

Wei Y, Zhu J . Associations between urinary concentrations of 2,5-dichlorophenol and metabolic syndrome among non-diabetic adults. Environ Sci Pollut Res Int. 2015; 23(1):581-8. DOI: 10.1007/s11356-015-5291-z. View

20.

Ishitsuka K, Nakayama S, Kishi R, Mori C, Yamagata Z, Ohya Y . Japan Environment and Children's Study: backgrounds, activities, and future directions in global perspectives. Environ Health Prev Med. 2017; 22(1):61. PMC: 5664803. DOI: 10.1186/s12199-017-0667-y. View