Comparative Analysis of Metabolic and Transcriptomic Features of

Overview

Journal J R Soc Interface

Specialties Biology
Biomedical Engineering
Biophysics

Date 2020 Jul 1

PMID 32603650

Citations 3

Authors

Maria Rita Fumagalli

Francesc Font-Clos

Simone Milan

Stefano Zapperi

Caterina A M La Porta

Affiliations

Soon will be listed here.

Abstract

Some species have a longer lifespan than others, but usually lifespan is correlated with typical body weight. Here, we study the lifetime evolution of the metabolic behaviour of , a killifish with an extremely short lifespan with respect to other fishes, even when taking into account rescaling by body weight. Comparison of the gene expression patterns of with those of zebrafish and mouse () shows that a broad set of metabolic genes and pathways are affected in during ageing in a way that is consistent with a global deregulation of chromatin. Computational analysis of the glycolysis pathway for the three species highlights a rapid increase in the metabolic activity during the lifetime of with respect to the other species. Our results highlight that the unusually short lifespan of is associated with peculiar patterns in the metabolic activities and in chromatin dynamics.

Citing Articles

Life in the fastlane? A comparative analysis of gene expression profiles across annual, semi-annual, and non-annual killifishes (Cyprinodontiformes: Nothobranchiidae).

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