Relationship of Health-related Variables to Levels of Anti-polyribosylribitol Phosphate Antibodies in Adults

Overview

Journal J Clin Microbiol

Specialty Microbiology

Date 1988 Jun 1

PMID 3260243

Authors

W M McDonnell

J R Gilsdorf

J B Kent

J N Sheagren

Affiliations

Soon will be listed here.

Abstract

To identify adults who may be at risk for Haemophilus influenzae type b disease by virtue of low levels of antibody against the H. influenzae b capsule and who may thus benefit from receiving H. influenzae b vaccine, we correlated serum anticapsular antibody levels of 388 adult patients with 26 health-related variables, including 3 personal characteristics, 10 laboratory values, 4 drug use categories, and 8 disease categories. Steroid use was consistently associated with low levels of anticapsular antibody; associations were also found between low antibody levels and both non-Caucasian race and increasing age. However, less than 4% of the antibody variability could be attributed to these factors, and they were not predictive of low antibody levels. Thus, although H. influenzae b infections are seen in adults with predisposing medical conditions, on the basis of the present findings, use of the H. influenzae b vaccine in adults cannot be recommended.

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