Serum C-reactive Protein to Albumin Ratio and Mortality Associated with Peritoneal Dialysis

Overview

Journal Ren Fail

Publisher Informa Healthcare

Date 2020 Jul 1

PMID 32602387

Citations 9

Authors

Siyi Liu

Panlin Qiu

Laimin Luo

Lei Jiang

Yanbing Chen

Caixia Yan

Xiaojiang Zhan

Affiliations

Soon will be listed here.

Abstract

Serum C-reactive protein to albumin ratio (CAR) was recently identified as a poor marker of prognosis among various populations. The current study aimed to examine the association between CAR and all-cause mortality among patients undergoing peritoneal dialysis (PD). A total of 758 patients with PD were included in this study during the period from 1 November 2005 to 28 February 2017 and followed up until 31 May 2017. The primary outcome was all-cause mortality. We used multivariate Cox proportional hazard models and Kaplan-Meier survival curves to assess the relationship between CAR and all-cause mortality in these patients. Among 758 participants, mean age was 49.1 ± 14.2 years, with 56% males and 18.6% prevalence of diabetes. Median CAR was 0.13 (interquartile range [IQR], 0.07-0.34). After 27 months (IQR, 14-40 months) of follow-up, 157 deaths had been reported. After adjusting for confounding factors, we found a significant association between serum CAR and all-cause mortality among those in the highest CAR group (hazard ratio 1.91, 95% confidence interval 1.05- 3.47, = 0.034). In patients undergoing PD, an increase in serum CAR is independently associated with increased risk for all-cause mortality.

Citing Articles

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Association between systemic immune inflammation Index and all-cause mortality in incident peritoneal dialysis-treated CKD patients: a multi-center retrospective cohort study.

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Interleukin-6-to-Albumin Ratio as a Superior Predictor of Mortality in End-Stage Kidney Disease Patients.

Li X, Qureshi A, Suliman M, Heimburger O, Barany P, Stenvinkel P Am J Nephrol. 2023; 54(7-8):268-274.

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