Chlorophyll-Based Near-Infrared Fluorescent Nanocomposites: Preparation and Optical Properties

Overview

Journal ACS Omega

Publisher American Chemical Society

Specialty Chemistry

Date 2020 Jun 30

PMID 32596562

Citations 1

Authors

Zhi-Liang Chen

Zi-Li Yu

Miao-Miao Zhou

Song Zhang

Bing Zhang

Yi Liu

Yi-Fang Zhao

Hui-Min Cao

Yi Lin

Zhi-Ling Zhang

Dai-Wen Pang

Affiliations

Soon will be listed here.

Abstract

Near-infrared (NIR) fluorescence has attracted much attention in biomedical fields because it offers deep tissue penetration and high spatial resolution. Herein, a method is developed for the preparation of NIR fluorescent nanocomposites (NCs) by encapsulating natural chlorophyll (Chl) into the micelles of octylamine-modified poly(acrylic acid) (OPA). Both femtosecond transient absorption spectra and isothermal titration calorimetry thermogram reveal that the micelles of OPA provide a hydrophobic environment for the improved fluorescence efficiency. Hence the resulted Chl NCs possess unique properties such as ultrasmall size, outstanding photostability, good biocompatibility, and superbright NIR fluorescence emission. In vivo imaging of sentinel lymph node is achieved in nude mice, demonstrating the potential of Chl NCs in biomedical applications. This work provides a new strategy for the preparation of highly biocompatible NIR fluorescence labeling nanocomposites.

Citing Articles

Bay Leaf Extract-Based Near-Infrared Fluorescent Probe for Tissue and Cellular Imaging.

Adriano B, Cotto N, Chauhan N, Karumuru V, Jaggi M, Chauhan S J Imaging. 2021; 7(12).

PMID: 34940722 PMC: 8705868. DOI: 10.3390/jimaging7120256.

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