A Novel TLX1-driven T-ALL Zebrafish Model: Comparative Genomic Analysis with Other Leukemia Models

Overview

Journal Leukemia

Specialties Hematology
Oncology

Date 2020 Jun 28

PMID 32591643

Citations 6

Authors

Siebe Loontiens

Suzanne Vanhauwaert

Lisa Depestel

Givani Dewyn

Wouter Van Loocke

Finola E Moore

Elaine G Garcia

Lance Batchelor

Chiara Borga

Barbara Squiban

Megan Malone-Perez

Pieter-Jan Volders

Volodimir Olexiouk

Pieter Van Vlierberghe

David M Langenau

J Kimble Frazer

Kaat Durinck

Frank Speleman

Affiliations

Soon will be listed here.

Citing Articles

Generation of a Zebrafish Knock-In Model Recapitulating Childhood ETV6::RUNX1-Positive B-Cell Precursor Acute Lymphoblastic Leukemia.

Zapilko V, Moisio S, Parikka M, Heinaniemi M, Lohi O Cancers (Basel). 2023; 15(24).

PMID: 38136366 PMC: 10871125. DOI: 10.3390/cancers15245821.

R274X-mutated Phf6 increased the self-renewal and skewed T cell differentiation of hematopoietic stem cells.

Lan Y, Yuan S, Guo T, Hou S, Zhao F, Yang W iScience. 2023; 26(6):106817.

PMID: 37288345 PMC: 10241978. DOI: 10.1016/j.isci.2023.106817.

Genomic landscape of T-cell lymphoblastic lymphoma.

Li Z, Song Y, Zhang M, Wei Y, Ruan H Chin J Cancer Res. 2022; 34(2):83-94.

PMID: 35685993 PMC: 9086577. DOI: 10.21147/j.issn.1000-9604.2022.02.03.

Mutations in Hematologic Malignancies.

Kurzer J, Weinberg O Front Oncol. 2021; 11:704471.

PMID: 34381727 PMC: 8350393. DOI: 10.3389/fonc.2021.704471.

Zebrafish models of acute leukemias: Current models and future directions.

Molina B, Chavez J, Grainger S Wiley Interdiscip Rev Dev Biol. 2020; 10(6):e400.

PMID: 33340278 PMC: 8213871. DOI: 10.1002/wdev.400.

References

Soto-Feliciano Y, Bartlebaugh J, Liu Y, Sanchez-Rivera F, Bhutkar A, Weintraub A . PHF6 regulates phenotypic plasticity through chromatin organization within lineage-specific genes. Genes Dev. 2017; 31(10):973-989. PMC: 5495126. DOI: 10.1101/gad.295857.117. View

De Keersmaecker K, Ferrando A . TLX1-induced T-cell acute lymphoblastic leukemia. Clin Cancer Res. 2011; 17(20):6381-6. DOI: 10.1158/1078-0432.CCR-10-3037. View

Kawabe T, Muslin A, Korsmeyer S . HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint. Nature. 1997; 385(6615):454-8. DOI: 10.1038/385454a0. View

Girardi T, Vicente C, Cools J, De Keersmaecker K . The genetics and molecular biology of T-ALL. Blood. 2017; 129(9):1113-1123. PMC: 5363819. DOI: 10.1182/blood-2016-10-706465. View

Hsu Y, Chen T, Lin C, Yuan C, Hsu C, Hou H . Phf6-null hematopoietic stem cells have enhanced self-renewal capacity and oncogenic potentials. Blood Adv. 2019; 3(15):2355-2367. PMC: 6693005. DOI: 10.1182/bloodadvances.2019000391. View

Borga C, Park G, Foster C, Burroughs-Garcia J, Marchesin M, Shah R . Simultaneous B and T cell acute lymphoblastic leukemias in zebrafish driven by transgenic MYC: implications for oncogenesis and lymphopoiesis. Leukemia. 2018; 33(2):333-347. PMC: 6365377. DOI: 10.1038/s41375-018-0226-6. View

Vanden Bempt M, Demeyer S, Broux M, De Bie J, Bornschein S, Mentens N . Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia. Cancer Cell. 2018; 34(2):271-285.e7. PMC: 6097876. DOI: 10.1016/j.ccell.2018.07.007. View

Pinz S, Unser S, Rascle A . Signal transducer and activator of transcription STAT5 is recruited to c-Myc super-enhancer. BMC Mol Biol. 2016; 17:10. PMC: 4831086. DOI: 10.1186/s12867-016-0063-y. View

Garcia E, Iyer S, Garcia S, Loontiens S, Sadreyev R, Speleman F . Cell of origin dictates aggression and stem cell number in acute lymphoblastic leukemia. Leukemia. 2018; 32(8):1860-1865. PMC: 6620784. DOI: 10.1038/s41375-018-0130-0. View

10.

Xie M, Lu C, Wang J, McLellan M, Johnson K, Wendl M . Age-related mutations associated with clonal hematopoietic expansion and malignancies. Nat Med. 2014; 20(12):1472-8. PMC: 4313872. DOI: 10.1038/nm.3733. View

11.

Thakral D, Kaur G, Gupta R, Benard-Slagter A, Savola S, Kumar I . Rapid Identification of Key Copy Number Alterations in B- and T-Cell Acute Lymphoblastic Leukemia by Digital Multiplex Ligation-Dependent Probe Amplification. Front Oncol. 2019; 9:871. PMC: 6753626. DOI: 10.3389/fonc.2019.00871. View

12.

Frazer J, Meeker N, Rudner L, Bradley D, Smith A, Demarest B . Heritable T-cell malignancy models established in a zebrafish phenotypic screen. Leukemia. 2009; 23(10):1825-35. PMC: 2761994. DOI: 10.1038/leu.2009.116. View

13.

White R, Rose K, Zon L . Zebrafish cancer: the state of the art and the path forward. Nat Rev Cancer. 2013; 13(9):624-36. PMC: 6040891. DOI: 10.1038/nrc3589. View

14.

Van Vlierberghe P, Palomero T, Khiabanian H, Van der Meulen J, Castillo M, Van Roy N . PHF6 mutations in T-cell acute lymphoblastic leukemia. Nat Genet. 2010; 42(4):338-42. PMC: 2847364. DOI: 10.1038/ng.542. View

15.

Meacham C, Lawton L, Soto-Feliciano Y, Pritchard J, Joughin B, Ehrenberger T . A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth. Genes Dev. 2015; 29(5):483-8. PMC: 4358400. DOI: 10.1101/gad.254151.114. View

16.

De Keersmaecker K, Real P, Della Gatta G, Palomero T, Sulis M, Tosello V . The TLX1 oncogene drives aneuploidy in T cell transformation. Nat Med. 2010; 16(11):1321-7. PMC: 2974790. DOI: 10.1038/nm.2246. View

17.

Wendorff A, Quinn S, Rashkovan M, Madubata C, Ambesi-Impiombato A, Litzow M . Loss Enhances HSC Self-Renewal Driving Tumor Initiation and Leukemia Stem Cell Activity in T-ALL. Cancer Discov. 2018; 9(3):436-451. PMC: 6425751. DOI: 10.1158/2159-8290.CD-18-1005. View

18.

Ribeiro D, Melao A, van Boxtel R, Santos C, Silva A, Silva M . STAT5 is essential for IL-7-mediated viability, growth, and proliferation of T-cell acute lymphoblastic leukemia cells. Blood Adv. 2018; 2(17):2199-2213. PMC: 6134214. DOI: 10.1182/bloodadvances.2018021063. View

19.

Durinck K, Van Loocke W, van der Meulen J, Van de Walle I, Ongenaert M, Rondou P . Characterization of the genome-wide TLX1 binding profile in T-cell acute lymphoblastic leukemia. Leukemia. 2015; 29(12):2317-27. DOI: 10.1038/leu.2015.162. View

20.

Langenau D, Traver D, Ferrando A, Kutok J, Aster J, Kanki J . Myc-induced T cell leukemia in transgenic zebrafish. Science. 2003; 299(5608):887-90. DOI: 10.1126/science.1080280. View