Association of MicroRNA-155rs767649 Polymorphism with Susceptibility to Preeclampsia

Overview

Journal Int J Mol Cell Med

Specialty Genetics

Date 2020 Jun 27

PMID 32587835

Citations 8

Authors

Shymaa E Ayoub

Olfat G Shaker

Mostafa Y Abdelwahed

Naglaa A Ahmed

Hazem G Abdelhameed

Almandouh H Bosilah

Sheren R Mohammed

Affiliations

Soon will be listed here.

Abstract

Preeclampsia (PE) is a multifactorial disorder. Several studies showed that micro RNAs may play a critical role in PE pathogenesis. We aimed to investigate for the first time the association of mir-155rs767649 polymorphism with PE. Eighty patients with preeclampsia and 80 normal subjects were enrolled in the study. Serum expression levels of mature mir-155were evaluated using real-time PCR, and mir-155 rs767649 (T/A) polymorphism was genotyped using TaqMan SNP genotyping. There was a significant difference between the expression level of mir-155 in cases (5.86 ± 3.11) in comparison with controls (0.58 ± 0.30) (P<0.0001)Also,the minor allele of rs767649 was significantly associated with increased risk of PE [Recessive model: adjusted Odds ratio (OR) = 5.240, 95% confidence interval (CI) = (1.999-13.733),P= 0.001]. There was a significant difference between different genotypes according to expression levels of mir-155 in PE (P<0.0001) with high expression levels in TA genotype (7.10 ± 3.11 ). Mir-155 may play a critical role in PE pathogenesis. The obtained data suggest that a minor allele of rs767649 might be a predisposing factor for PE.

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