T-cell Acute Childhood Lymphoblastic Leukemia with Chromosome 14 Q 11 Anomaly: a Morphologic, Immunologic, and Cytogenetic Analysis of 10 Patients

Overview

Journal Blut

Specialty Hematology

Date 1988 Mar 1

PMID 3258538

Citations 4

Authors

F Lampert

J Harbott

J Ritterbach

W D Ludwig

C Fonatsch

D Schwamborn

B Stier

A Gnekow

V Gerein

B Stollmann

Affiliations

Soon will be listed here.

Abstract

Ten patients with T-cell acute lymphoblastic leukemia (ALL) and a chromosome anomaly involving band 14 q 11 are described. Mitotic index of bone marrow blasts was high in all patients (average 3.0%). Lymphoid morphology of the leukemic blasts, however, varied somewhat among the patients. The leukemic cells of 5 patients showed an immunophenotypic profile corresponding to early or common thymic differentiation stages whereas 5 children showed strong expression of CD 3 suggesting a more mature thymic phenotype. Leukemic karyotypes revealed a modal chromosome number of 46 in 9 cases, 92 in one case. A chromosome translocation t(11; 14) (p 13; q 11) was found in 5 cases, a t(1; 14) (p 32; q 11) in 2 cases, a t(10; 14) (q 24; q 11) in one case, a (hitherto undescribed) t(12; 14) (q 22; q 11) in one case, and an inv (14) (q 11 q 32) in one patient. Additional abnormalities were t(3; 10), t(7; 9), dup(7 q), del(6 q), del(10 q), and del(1 q). Of 32 cases with T-cell ALL successfully karyotyped in our laboratory 15 (= 47%) had structural aberrations involving chromosomes 1, 3, 6, 7, 9, 10, 12, 14. Ten of these 15 patients (= 67%) had a chromosome 14 q 11 anomaly. It is concluded that chromosome band 14 q 11, the gene locus of the T-cell receptor alpha-chain, is the most common site for structural chromosome aberrations in T-cell ALL.

Citing Articles

Inv(14) with distal breakpoint in 14q32.1 in three cases of T cell lymphoma.

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The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein.

Chen Q, Cheng J, Tasi L, Schneider N, Buchanan G, Carroll A EMBO J. 1990; 9(2):415-24.

PMID: 2303035 PMC: 551682. DOI: 10.1002/j.1460-2075.1990.tb08126.x.

Frequency and DNA sequence of tal-1 rearrangement in children with T-cell acute lymphoblastic leukemia.

Borkhardt A, Repp R, Harbott J, Keller C, Berner F, Ritterbach J Ann Hematol. 1992; 64(6):305-8.

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Chromosomal localization of HTLV-1 viral integration sites using in situ hybridization: detection of a novel IL2R fragment.

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