Interleukin 1 Modulates Collagen Accumulation by Rat Granulation Tissue Cells Both in Vivo and in Vitro

Overview

Journal Experientia

Specialty Science

Date 1988 Jan 15

PMID 3258249

Citations 2

Authors

M Laato

J Heino

Affiliations

Soon will be listed here.

Abstract

In in vivo studies 0.5 U human interleukin 1 (IL-1) was inoculated daily into a subcutaneously implanted viscose cellulose sponge. IL-1 significantly decreased the dry weight (7.8%) and the hydroxyproline content (24.2%) of granulomas. When the cultured rat granulation tissue cells were exposed to IL-1 (0.5-2.0 U/ml) their collagen production decreased to 80% of that in controls. No effect on cell proliferation was detected.

Citing Articles

Inhibition of collagen synthesis by interleukin-1 in three-dimensional collagen lattice cultures of fibroblasts.

Gillery P, Coustry F, Pujol J, Borel J Experientia. 1989; 45(1):98-101.

PMID: 2783575 DOI: 10.1007/BF01990461.

Interleukin-1 beta prevents the stimulatory effect of transforming growth factor-beta on collagen gene expression in human skin fibroblasts.

Heino J, Heinonen T Biochem J. 1990; 271(3):827-30.

PMID: 2244882 PMC: 1149639. DOI: 10.1042/bj2710827.

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