Novel Assessment of Unruptured Intracranial Aneurysm Inflammatory Factors

Overview

Journal Front Neurol

Specialty Neurology

Date 2020 Jun 26

PMID 32582003

Citations 3

Authors

Steve M Cordina

Shant Afarian

William T Gerthoffer

Anthony Martino

Russell Wilson

Dean K Naritoku

Affiliations

Soon will be listed here.

Abstract

The growth and eventual rupture of intracranial aneurysms may be due to an underlying inflammatory process as evidenced by pathological examination of aneurysm walls. We hypothesize that unruptured aneurysms have an increased inflammatory milieu within their lumen in comparison to the rest of the cerebral arterial vascular system. Blood was sampled from unruptured aneurysms in patients presenting for aneurysm coil embolization and C3 and C4 complement values from this serum were compared with complement values in the parent artery. Ten patients were enrolled over 32 months with a mean aneurysm size of 9.1 mm. Compared to control samples drawn from peripheral circulation, there were significant decreases of both C3 ( = 0.0003) and C4 ( = 0.0063) levels in aneurysmal blood samples. A state of decreased complement indicative of classic pathway activation was found in all tested aneurysms, thus providing evidence of an ongoing process of complement activation in the blood of live, unruptured aneurysm sacs.

Citing Articles

Intraluminal assessment of inflammatory factors in patients with intracranial aneurysms.

Boulieris S, Zampakis P, Panagoulias I, Mouzaki A, Constantoyannis C, Theofanopoulos A Acta Neurochir (Wien). 2023; 165(12):3685-3695.

PMID: 37882876 DOI: 10.1007/s00701-023-05851-9.

Growth and rupture of an intracranial aneurysm: the role of wall aneurysmal enhancement and CD68.

Cannizzaro D, Zaed I, Olei S, Fernandes B, Peschillo S, Milani D Front Surg. 2023; 10:1228955.

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The Role of Soluble Urokinase Plasminogen Activator Receptor (suPAR) in the Context of Aneurysmal Subarachnoid Hemorrhage (aSAH)-A Prospective Observational Study.

Schmidt T, Albanna W, Weiss M, Veldeman M, Conzen C, Nikoubashman O Front Neurol. 2022; 13:841024.

PMID: 35359651 PMC: 8960720. DOI: 10.3389/fneur.2022.841024.

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