3-(Phenethylamino)demethyl(oxy)aaptamine As an Anti-dormant Mycobacterial Substance: Isolation, Evaluation and Total Synthesis

Overview

Journal Tetrahedron Lett

Publisher Elsevier

Specialty Chemistry

Date 2020 Jun 25

PMID 32577043

Citations 5

Authors

Yuji Sumii

Naoyuki Kotoku

Chisu Han

Kentaro Kamiya

Andi Setiawan

Catherine Vilcheze

William R Jacobs Jr

Masayoshi Arai

Affiliations

Soon will be listed here.

Abstract

3-(Phenethylamino)demethyl(oxy)aaptamine () was re-discovered from the marine sponge of sp. as an anti-dormant mycobacterial substance through the bioassay-guided separation. Compound showed potent anti-microbial activity against BCG with a minimum inhibitory concentration of 0.75 µg/mL under both aerobic conditions and hypoxic conditions inducing dormant state. Compound was also effective against pathogenic strains including clinical multidrug-resistant strains. Furthermore, the successful total syntheses of and its analog 3-aminodemethyl(oxy)aaptamine () afford sufficient quantities for further biological studies.

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