Effects of Injectable Trace Minerals (ITMs) on Th1/Th2 Cytokine Balance of Newborn Calves with Tropical Theileriosis

Overview

Journal Biol Trace Elem Res

Date 2020 Jun 24

PMID 32572800

Citations 3

Authors

Pradeep K Ram

Shanker K Singh

Ashish Srivastava

Gulshan Kumar

Amit K Jaiswal

Brijesh Yadav

Satish K Garg

Affiliations

Soon will be listed here.

Abstract

Injectable trace minerals (ITMs) could provide a potential alternative way of trace mineral delivery for sick animals. Therefore, evaluation of ameliorative potentials of ITMs (copper, manganese, selenium, and zinc) on the circulating Th1/Th2 cytokine misbalance in Theileria annulata-infected calves was aimed. Forty-three T. annulata-infected newborn calves were randomly allocated into four groups: buparvaquone alone-treated group (BUPA), buparvaquone + oxytetracycline (BUPA + OXY)-treated group, buparvaquone + injectable trace minerals (BUPA + ITMs)-treated group, and BUPA + OXY + ITM-treated group. Blood samples were collected from each of the calves before the start of therapy (day 0) and on day 14 post-therapy. Serum contents of pro- and anti-inflammatory cytokines were estimated by bovine specific ELISA kits. On day 14 post-therapy, significant amelioration in the circulating levels of the studied cytokines was not observed in the calves treated with BUPA, while the calves treated with BUPA + OXY revealed significant (P ≤ 0.04) amelioration in the circulating tumour necrosis factor-α (TNF-α) level. The calves treated with BUPA + ITMs revealed significant (P ≤ 0.041) elevation in the circulating interferon-γ (IFN-γ) and significant (P ≤ 0.011) reduction in the interleukin-10 (IL-10) levels. Moreover, the calves treated with BUPA + OXY + ITMs revealed significant reduction in TNF-α (P ≤ 0.0001) and IL-10 (P ≤ 0.012) contents, and significant elevation in IFN-γ (P ≤ 0.0002) content on day 14 post-therapy. None of the treated calve group revealed significant alteration in the circulating level of transforming growth factor-β (TGF-β) on day 14 post-therapy. In conclusion, administration of ITMs to the therapeutic regimen of newborn calves with tropical theileriosis could be a promising therapeutic strategy. ITMs can be recommended for the amelioration of immunological misbalance due to tropical theileriosis in newborn calves.

Citing Articles

The interplay of cytokines in bovine tropical theileriosis: a mini review.

Sudan V, Paliwal S Trop Anim Health Prod. 2024; 56(5):174.

PMID: 38787525 DOI: 10.1007/s11250-024-04021-y.

The Effects of Zinc Supplementation on Growth, Diarrhea, Antioxidant Capacity, and Immune Function in Holstein Dairy Calves.

Liu J, Ma F, Degen A, Sun P Animals (Basel). 2023; 13(15).

PMID: 37570301 PMC: 10417456. DOI: 10.3390/ani13152493.

The phenotypic and haemato-biochemical appraisal of tropical theileriosis in newborn calves.

Ram P, Singh S, Sudan V Trop Anim Health Prod. 2021; 53(5):477.

PMID: 34557986 DOI: 10.1007/s11250-021-02889-8.

References

Vazquez M, Catalan-Dibene J, Zlotnik A . B cells responses and cytokine production are regulated by their immune microenvironment. Cytokine. 2015; 74(2):318-26. PMC: 4475485. DOI: 10.1016/j.cyto.2015.02.007. View

Deroost K, Pham T, Opdenakker G, Van den Steen P . The immunological balance between host and parasite in malaria. FEMS Microbiol Rev. 2015; 40(2):208-57. DOI: 10.1093/femsre/fuv046. View

Percario S, Moreira D, Gomes B, Ferreira M, Goncalves A, Laurindo P . Oxidative stress in malaria. Int J Mol Sci. 2012; 13(12):16346-72. PMC: 3546694. DOI: 10.3390/ijms131216346. View

Gupta A, Gupta K, Leishangthem G, Bal M, Sood N, Singh A . Molecular and pathological studies on natural cases of bovine theileriosis. J Parasit Dis. 2017; 41(1):211-218. PMC: 5339203. DOI: 10.1007/s12639-016-0781-6. View

Razmi G, Yaghfoori S, Mohri M, Haghparast A, Tajeri S . The haematological, proinflammatory cytokines and IgG changes during an ovine experimental theileriosis. Onderstepoort J Vet Res. 2019; 86(1):e1-e6. PMC: 6407460. DOI: 10.4102/ojvr.v86i1.1629. View

Moore K, Vieira P, Fiorentino D, Trounstine M, Khan T, Mosmann T . Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI. Science. 1990; 248(4960):1230-4. DOI: 10.1126/science.2161559. View

Howard M, OGarra A . Biological properties of interleukin 10. Immunol Today. 1992; 13(6):198-200. DOI: 10.1016/0167-5699(92)90153-X. View

Soman S, Singh S, Kumari P, Choudhury S, Singh A, Kanwal S . Quantification of immuno-regulatory cytokine and toll-like receptors gene expression in dogs with generalized demodicosis. Vet Parasitol. 2020; 280:109063. DOI: 10.1016/j.vetpar.2020.109063. View

Plattner F, Soldati-Favre D . Hijacking of host cellular functions by the Apicomplexa. Annu Rev Microbiol. 2008; 62:471-87. DOI: 10.1146/annurev.micro.62.081307.162802. View

10.

Rashid M, Guan G, Luo J, Zhao S, Wang X, Rashid M . Establishment and Expression of Cytokines in a -Infected Bovine B Cell Line. Genes (Basel). 2019; 10(5). PMC: 6562936. DOI: 10.3390/genes10050329. View

11.

Campbell J, Howie S, Odling K, Glass E . Theileria annulata induces abberrant T cell activation in vitro and in vivo. Clin Exp Immunol. 1995; 99(2):203-10. PMC: 1534289. DOI: 10.1111/j.1365-2249.1995.tb05533.x. View

12.

Spears J . Micronutrients and immune function in cattle. Proc Nutr Soc. 2000; 59(4):587-94. DOI: 10.1017/s0029665100000835. View

13.

Yadav B, Singh S, Nakade U, Singh V, Sharma A, Srivastava M . Ameliorative Potential of Prepartal Trace Mineral and Vitamin Supplementation on Parturition-Induced Redox Balance and Myeloperoxidase Activity of Periparturient Sahiwal Cows. Biol Trace Elem Res. 2016; 177(1):72-79. DOI: 10.1007/s12011-016-0864-3. View

14.

Rabiee A, Lean I, Stevenson M, Socha M . Effects of feeding organic trace minerals on milk production and reproductive performance in lactating dairy cows: a meta-analysis. J Dairy Sci. 2010; 93(9):4239-51. DOI: 10.3168/jds.2010-3058. View

15.

Nockels C, DeBonis J, Torrent J . Stress induction affects copper and zinc balance in calves fed organic and inorganic copper and zinc sources. J Anim Sci. 1993; 71(9):2539-45. DOI: 10.2527/1993.7192539x. View

16.

Roche J, Friggens N, Kay J, Fisher M, Stafford K, Berry D . Invited review: Body condition score and its association with dairy cow productivity, health, and welfare. J Dairy Sci. 2009; 92(12):5769-801. DOI: 10.3168/jds.2009-2431. View

17.

Guergnon J, Chaussepied M, Sopp P, Lizundia R, Moreau M, Blumen B . A tumour necrosis factor alpha autocrine loop contributes to proliferation and nuclear factor-kappaB activation of Theileria parva-transformed B cells. Cell Microbiol. 2003; 5(10):709-16. DOI: 10.1046/j.1462-5822.2003.00314.x. View

18.

Dabak M, Dabak D, Aktas M . Cerebral theileriosis in a Holstein calf. Vet Rec. 2004; 154(17):533-4. DOI: 10.1136/vr.154.17.533. View

19.

Mbwambo H, Magwisha H, Mfinanga J . Evaluation of buparvaquone (BUTA-Kel KELA, Belgium) as a treatment of East Coast fever in cattle, in the peri-urban of Dar Es Salaam city, Tanzania. Vet Parasitol. 2006; 139(1-3):67-73. DOI: 10.1016/j.vetpar.2006.02.024. View

20.

Jarosz L, Marek A, Gradzki Z, Kwiecien M, Zylinska B, Kaczmarek B . Effect of feed supplementation with zinc glycine chelate and zinc sulfate on cytokine and immunoglobulin gene expression profiles in chicken intestinal tissue. Poult Sci. 2017; 96(12):4224-4235. DOI: 10.3382/ps/pex253. View