Antibiotic Resistance in Nosocomial Bacteria Isolated from Infected Wounds of Hospitalized Patients in Czech Republic

Overview

Journal Antibiotics (Basel)

Specialty Pharmacology

Date 2020 Jun 24

PMID 32570909

Citations 3

Authors

Milan Kolar

Pavel cermak

Lenka Hobzova

Katerina Bogdanova

Katerina Neradova

Patrik Mlynarcik

Pavel Bostik

Affiliations

Soon will be listed here.

Abstract

Hospitalized patients with wounds face an increased risk of infection with multi-drug-resistant nosocomial bacteria. In this study, samples from almost 10,000 patients from big hospitals in Czech Republic with infected wounds were analyzed for the presence of bacterial pathogens. In 7693 patients (78.8%), bacterial etiological agents were identified. Members of the (37.1%) and (21.1%) were the most prevalent pathogens. showed methicillin resistance in 8.6%. Almost half of the isolates were ESBL-positive and 25.6% of the spp. isolates were AmpC-positive. The third most prevalent showed resistance to 19-32% of the antipseudomonal antibiotics tested. Based on the results, amoxicillin/clavulanic acid, ampicillin/sulbactam or piperacillin/tazobactam combined with gentamicin can be recommended for antibiotic treatment of infected wounds. Once the etiological agent is identified, the therapy should be adjusted according to the species and its resistance.

Citing Articles

Microbial Species Isolated from Infected Wounds and Antimicrobial Resistance Analysis: Data Emerging from a Three-Years Retrospective Study.

Puca V, Marulli R, Grande R, Vitale I, Niro A, Molinaro G Antibiotics (Basel). 2021; 10(10).

PMID: 34680743 PMC: 8532735. DOI: 10.3390/antibiotics10101162.

Strong Antimicrobial and Healing Effects of Beta-Acids from Hops in Methicillin-Resistant -Infected External Wounds In Vivo.

Sleha R, Radochova V, Malis J, Mikyska A, Houska M, Krofta K Antibiotics (Basel). 2021; 10(6).

PMID: 34204644 PMC: 8231114. DOI: 10.3390/antibiotics10060708.

Implementation of Antibiotic Stewardship in a University Hospital Setting.

Kolar M, Htoutou Sedlakova M, Urbanek K, Mlynarcik P, Roderova M, Hricova K Antibiotics (Basel). 2021; 10(1).

PMID: 33477923 PMC: 7833368. DOI: 10.3390/antibiotics10010093.

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