» Articles » PMID: 32568094

Atlas of the OMERACT Heel Enthesitis MRI Scoring System (HEMRIS)

Abstract

Objective: Assessment of enthesitis, a key feature in spondyloarthritis (SpA) and psoriatic arthritis (PsA), using objective and sensitive methods is pivotal in clinical trials. MRI allows detection of both soft tissue and intra-osseous changes of enthesitis. This article presents an atlas for the Outcome Measures in Rheumatology (OMERACT) Heel Enthesitis Magnetic Resonance ImagingMRI Scoring System (HEMRIS).

Methods: Following a preliminary selection of potential examples of each grade, as per HEMRIS definitions, the images along with detailed definitions and reader rules were discussed at web-based, interactive meetings between the members of the OMERACT MRI in Arthritis Working Group.

Results: Reference images of each grade of the MRI features to be assessed using HEMRIS, along with reader rules and recommended MRI sequences are depicted.

Conclusion: The presented reference images can be used to guide scoring Achilles tendon and plantar fascia (plantar aponeurosis) enthesitis according to the OMERACT HEMRIS in clinical trials and cohorts in which MRI enthesitis is used as an outcome.

Citing Articles

Pivotal role of the synovioentheseal complex in the imaging of arthritis and rheumatic diseases.

Yildiz A, Aydingoz U Diagn Interv Radiol. 2024; 30(6):409-418.

PMID: 38856322 PMC: 11589525. DOI: 10.4274/dir.2024.242740.


Longitudinal Follow-Up Using the Heel Enthesitis Magnetic Resonance Imaging Scoring System (HEMRIS) Shows Minimal Changes in Heel Enthesitis Assessed in Spondyloarthritis and Psoriasis Patients.

Kleinrensink N, Foppen W, Ten Katen I, Leijten E, de Jong P, Spierings J J Pers Med. 2022; 12(11).

PMID: 36573712 PMC: 9693157. DOI: 10.3390/jpm12111765.


A clinical practice guideline for the screening and assessment of enthesitis in patients with spondyloarthritis.

Wu X, Liu D, Li Y, Xie Y, Tu L, Zhang Y Front Immunol. 2022; 13:978504.

PMID: 36172360 PMC: 9510351. DOI: 10.3389/fimmu.2022.978504.


Magnetic resonance imaging characteristics in patients with spondyloarthritis and clinical diagnosis of heel enthesitis: post hoc analysis from the phase 3 ACHILLES trial.

Baraliakos X, Sewerin P, De Miguel E, Pournara E, Kleinmond C, Shekhawat A Arthritis Res Ther. 2022; 24(1):111.

PMID: 35578245 PMC: 9109380. DOI: 10.1186/s13075-022-02797-8.


Comparison of the Heel Enthesitis MRI Scoring System (HEMRIS) with clinical enthesitis and local metabolic activity on PET-CT.

Kleinrensink N, Foppen W, Ten Katen I, van der Veen P, de Klerk B, Diepstraten S RMD Open. 2020; 6(3).

PMID: 33277402 PMC: 7856158. DOI: 10.1136/rmdopen-2020-001424.


References
1.
Mathew A, Krabbe S, Kirubakaran R, Barr A, Conaghan P, Bird P . Utility of Magnetic Resonance Imaging in Diagnosis and Monitoring Enthesitis in Patients with Spondyloarthritis: An OMERACT Systematic Literature Review. J Rheumatol. 2019; 46(9):1207-1214. DOI: 10.3899/jrheum.181083. View

2.
Benjamin M, McGonagle D . The anatomical basis for disease localisation in seronegative spondyloarthropathy at entheses and related sites. J Anat. 2002; 199(Pt 5):503-26. PMC: 1468363. DOI: 10.1046/j.1469-7580.2001.19950503.x. View

3.
Benjamin M, Moriggl B, Brenner E, Emery P, McGonagle D, Redman S . The "enthesis organ" concept: why enthesopathies may not present as focal insertional disorders. Arthritis Rheum. 2004; 50(10):3306-13. DOI: 10.1002/art.20566. View

4.
McGonagle D, Gibbon W, OConnor P, Green M, Pease C, Emery P . Characteristic magnetic resonance imaging entheseal changes of knee synovitis in spondylarthropathy. Arthritis Rheum. 1998; 41(4):694-700. DOI: 10.1002/1529-0131(199804)41:4<694::AID-ART17>3.0.CO;2-#. View

5.
Lambert R, Dhillon S, Jhangri G, Sacks J, Sacks H, Wong B . High prevalence of symptomatic enthesopathy of the shoulder in ankylosing spondylitis: deltoid origin involvement constitutes a hallmark of disease. Arthritis Rheum. 2004; 51(5):681-90. DOI: 10.1002/art.20681. View