The Diagnostic and Clinical Significance of TFE3 Immunohistochemical Nuclear Expression in Solitary Fibrous Tumour

Overview

Journal Anal Cell Pathol (Amst)

Specialties Cell Biology
Oncology
Pathology

Date 2020 Jun 23

PMID 32566457

Citations 3

Authors

Luting Zhou

Anran Wang

Guoli Yu

Jun Zhou

Haimin Xu

Chaofu Wang

Affiliations

Soon will be listed here.

Abstract

The expression of TFE3 (transcription factor E3) in solitary fibrous tumours (SFTs) and their histologic mimickers was investigated, and the diagnostic value and clinical significance of TFE3 nuclear expression in SFTs were explored. Immunohistochemical analysis for TFE3 was performed on 50 cases of SFTs that were surgically resected. The controls were sample tissues from malignant peripheral nerve sheath tumour, synovial sarcoma, dedifferentiated liposarcoma, spindle cell lipoma, and dermatofibrosarcoma protuberans. The survival of patients with TFE3-positive and TFE3-negative expressions was assessed through the Kaplan-Meier analysis. In 44 of 50 (88%) SFTs, nuclear immunoreactivity for TFE3 was detected. The TFE3 expression was negative in all samples of synovial sarcoma, malignant peripheral nerve sheath tumour, dermatofibrosarcoma protuberans, and spindle cell lipoma and weakly positive in 2 of 10 cases of dedifferentiated liposarcoma. Fluorescence in situ hybridization (FISH) confirmed that the expression of the TFE3 protein is not caused by gene translocation. There was no statistical significance between the association of the TFE3 expression and SFT patient prognosis. Therefore, TFE3 is capable of enhancing the differential diagnosis of SFTs and their histologic mimickers and can be potentially used as a diagnostic marker. The findings also offer valuable insights into SFT diagnosis, aetiology, and associated molecular mechanisms.

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References

Brady O, Jeong E, Martina J, Pirooznia M, Tunc I, Puertollano R . The transcription factors TFE3 and TFEB amplify p53 dependent transcriptional programs in response to DNA damage. Elife. 2018; 7. PMC: 6292694. DOI: 10.7554/eLife.40856. View

Haq R, Fisher D . Biology and clinical relevance of the micropthalmia family of transcription factors in human cancer. J Clin Oncol. 2011; 29(25):3474-82. DOI: 10.1200/JCO.2010.32.6223. View

Schoolmeester J, Lastra R . Granular cell tumors overexpress TFE3 without corollary gene rearrangement. Hum Pathol. 2015; 46(8):1242-3. DOI: 10.1016/j.humpath.2015.04.004. View

Robinson D, Wu Y, Kalyana-Sundaram S, Cao X, Lonigro R, Sung Y . Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing. Nat Genet. 2013; 45(2):180-5. PMC: 3654808. DOI: 10.1038/ng.2509. View

Vivero M, Doyle L, Fletcher C, Mertens F, Hornick J . GRIA2 is a novel diagnostic marker for solitary fibrous tumour identified through gene expression profiling. Histopathology. 2014; 65(1):71-80. DOI: 10.1111/his.12377. View

STOUT A, Murray M . HEMANGIOPERICYTOMA: A VASCULAR TUMOR FEATURING ZIMMERMANN'S PERICYTES. Ann Surg. 1942; 116(1):26-33. PMC: 1543753. DOI: 10.1097/00000658-194207000-00004. View

Martina J, Diab H, Lishu L, Jeong-A L, Patange S, Raben N . The nutrient-responsive transcription factor TFE3 promotes autophagy, lysosomal biogenesis, and clearance of cellular debris. Sci Signal. 2014; 7(309):ra9. PMC: 4696865. DOI: 10.1126/scisignal.2004754. View

Ploper D, Taelman V, Robert L, Perez B, Titz B, Chen H . MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells. Proc Natl Acad Sci U S A. 2015; 112(5):E420-9. PMC: 4321275. DOI: 10.1073/pnas.1424576112. View

Jimbo N, Nishigami T, Noguchi M, Iijima H, Hirota S, Tajiri T . Hepatic angiomyolipomas may overexpress TFE3, but have no relevant genetic alterations. Hum Pathol. 2016; 61:41-48. DOI: 10.1016/j.humpath.2016.11.003. View

10.

Westra W, Gerald W, Rosai J . Solitary fibrous tumor. Consistent CD34 immunoreactivity and occurrence in the orbit. Am J Surg Pathol. 1994; 18(10):992-8. DOI: 10.1097/00000478-199410000-00003. View

11.

Fukunaga M, Naganuma H, Nikaido T, Harada T, Ushigome S . Extrapleural solitary fibrous tumor: a report of seven cases. Mod Pathol. 1997; 10(5):443-50. View

12.

Steingrimsson E, Copeland N, Jenkins N . Melanocytes and the microphthalmia transcription factor network. Annu Rev Genet. 2004; 38:365-411. DOI: 10.1146/annurev.genet.38.072902.092717. View

13.

Dry S, Fletcher C . Atypical and malignant solitary fibrous tumors in extrathoracic locations: evidence of their comparability to intra-thoracic tumors. Am J Surg Pathol. 1998; 22(12):1501-11. DOI: 10.1097/00000478-199812000-00007. View

14.

Agaram N, Sung Y, Zhang L, Chen C, Chen H, Singer S . Dichotomy of Genetic Abnormalities in PEComas With Therapeutic Implications. Am J Surg Pathol. 2015; 39(6):813-25. PMC: 4431898. DOI: 10.1097/PAS.0000000000000389. View

15.

Hodge J, Pearce K, Wang X, Wiktor A, Oliveira A, Greipp P . Molecular cytogenetic analysis for TFE3 rearrangement in Xp11.2 renal cell carcinoma and alveolar soft part sarcoma: validation and clinical experience with 75 cases. Mod Pathol. 2013; 27(1):113-27. DOI: 10.1038/modpathol.2013.83. View

16.

Lee H, Shin D, Kim S, Hwang C, Lee J, Park W . TFE3 translocation and protein expression in renal cell carcinoma are correlated with poor prognosis. Histopathology. 2018; 73(5):758-766. DOI: 10.1111/his.13700. View

17.

Steingrimsson E, Tessarollo L, Pathak B, Hou L, Arnheiter H, Copeland N . Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development. Proc Natl Acad Sci U S A. 2002; 99(7):4477-82. PMC: 123673. DOI: 10.1073/pnas.072071099. View

18.

Willett R, Martina J, Zewe J, Wills R, Hammond G, Puertollano R . TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes. Nat Commun. 2017; 8(1):1580. PMC: 5691037. DOI: 10.1038/s41467-017-01871-z. View

19.

Napolitano G, Ballabio A . TFEB at a glance. J Cell Sci. 2016; 129(13):2475-81. PMC: 4958300. DOI: 10.1242/jcs.146365. View

20.

Fukunaga M, Naganuma H, Ushigome S, Endo Y, Ishikawa E . Malignant solitary fibrous tumour of the peritoneum. Histopathology. 1996; 28(5):463-6. DOI: 10.1046/j.1365-2559.1996.297345.x. View