Malaria According to GARP: A New Trail Towards Anti-disease Vaccination

Overview

Journal Trends Parasitol

Specialty Parasitology

Date 2020 Jun 22

PMID 32563704

Citations 3

Authors

Calvin Hon

Kai Matuschewski

Affiliations

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Abstract

Naturally acquired anti-Plasmodium falciparum immunity protects first and foremost against severe disease. Raj et al. have established a tantalizing path towards an anti-disease vaccine by identifying glutamic acid-rich protein (GARP) antibodies as signatures of protection against severe malaria in Tanzanian children and demonstrating efficacy in blood cultures and monkey trials.

Citing Articles

Analysis of sequence diversity in Plasmodium falciparum glutamic acid-rich protein (PfGARP), an asexual blood stage vaccine candidate.

Rojrung R, Kuamsab N, Putaporntip C, Jongwutiwes S Sci Rep. 2023; 13(1):3951.

PMID: 36894624 PMC: 9996596. DOI: 10.1038/s41598-023-30975-4.

A multi-epitope vaccine designed against blood-stage of malaria: an immunoinformatic and structural approach.

Atapour A, Vosough P, Jafari S, Sarab G Sci Rep. 2022; 12(1):11683.

PMID: 35804032 PMC: 9266094. DOI: 10.1038/s41598-022-15956-3.

Of membranes and malaria: phospholipid asymmetry in Plasmodium falciparum-infected red blood cells.

Fraser M, Matuschewski K, Maier A Cell Mol Life Sci. 2021; 78(10):4545-4561.

PMID: 33713154 PMC: 11071739. DOI: 10.1007/s00018-021-03799-6.