Epigenome-wide Association Study of Attention-deficit/hyperactivity Disorder in Adults

Overview

Journal Transl Psychiatry

Specialties Psychiatry
Public Health

Date 2020 Jun 21

PMID 32561708

Citations 10

Authors

Paula Rovira

Cristina Sanchez-Mora

Mireia Pagerols

Vanesa Richarte

Montserrat Corrales

Christian Fadeuilhe

Laura Vilar-Ribo

Lorena Arribas

Gemma Shireby

Eilis Hannon

Jonathan Mill

Miquel Casas

Josep Antoni Ramos-Quiroga

Maria Soler Artigas

Marta Ribases

Affiliations

Soon will be listed here.

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable neurodevelopmental disorder that often persists into adulthood. There is growing evidence that epigenetic dysregulation participates in ADHD. Given that only a limited number of epigenome-wide association studies (EWASs) of ADHD have been conducted so far and they have mainly focused on pediatric and population-based samples, we performed an EWAS in a clinical sample of adults with ADHD. We report one CpG site and four regions differentially methylated between patients and controls, which are located in or near genes previously involved in autoimmune diseases, cancer or neuroticism. Our sensitivity analyses indicate that smoking status is not responsible for these results and that polygenic risk burden for ADHD does not greatly impact the signatures identified. Additionally, we show an overlap of our EWAS findings with genetic signatures previously described for ADHD and with epigenetic signatures for smoking behavior and maternal smoking. These findings support a role of DNA methylation in ADHD and emphasize the need for additional efforts in larger samples to clarify the role of epigenetic mechanisms on ADHD across the lifespan.

Citing Articles

Cortico-striatal differences in the epigenome in attention-deficit/ hyperactivity disorder.

Shastri G, Sudre G, Ahn K, Jung B, Kolachana B, Auluck P Transl Psychiatry. 2024; 14(1):189.

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An overview on neurobiology and therapeutics of attention-deficit/hyperactivity disorder.

da Silva B, Grevet E, Silva L, Ramos J, Rovaris D, Bau C Discov Ment Health. 2023; 3(1):2.

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Correlation of the methylomic signature of smoking during pregnancy with clinical traits in ADHD.

Chaumette B, Grizenko N, Fageera W, Fortier M, Ter-Stepanian M, Labbe A J Psychiatry Neurosci. 2023; 48(5):E390-E399.

PMID: 37857414 PMC: 10599658. DOI: 10.1503/jpn.230062.

DNA methylation is associated with prenatal exposure to sulfur dioxide and childhood attention-deficit hyperactivity disorder symptoms.

Choi Y, Cho J, Hong Y, Lee D, Moon S, Park S Sci Rep. 2023; 13(1):3501.

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Polygenic risk score for attention-deficit/hyperactivity disorder and brain functional networks segregation in a community-based sample.

Sato J, Biazoli C, Bueno A, Caye A, Pan P, Santoro M Genes Brain Behav. 2023; 22(2):e12838.

PMID: 36811275 PMC: 10067387. DOI: 10.1111/gbb.12838.

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