Predictive Value of the Sentinel Lymph Node Procedure in the Staging of Non-metastatic Colorectal Cancer

Overview

Journal Int J Colorectal Dis

Specialties Gastroenterology
General Surgery

Date 2020 Jun 20

PMID 32556650

Citations 10

Authors

A Carrara

M Motter

D Amabile

L Pellecchia

P Moscatelli

R Pertile

M Barbareschi

N L Decarli

M Ferrari

G Tirone

Affiliations

Soon will be listed here.

Abstract

Purpose: Despite the recent growing interest of the scientific community, there is still no consensus on the actual applicability and effectiveness of sentinel lymph node (SL) procedure in colon cancers. This study aims to quantify feasibility, detection rate, negative predictive value, and accuracy of the SL identified with fluorescent dye in early colon cancers (ECC).

Methods: This study conducted a consecutive sampling of 95 patients with non-metastatic colorectal cancer who have been treated with laparoscopic colon resection and complete mesocolic excision after a 25-mg indocyanine green peritumoral laparoscopic injection and SL identification with a near-infrared camera. The SL was later isolated and sent to ultra-staging.

Results: Ninety-five patients with an average age of 71 (range 37-90) and a mean BMI of 25 (range 18-39) have been recruited. On the patient sample (92 Pts), an average of 1.49 SL (range 1-5) and a mean time of 4 min were identified. The detection rate was 96.8% and the negative predictive value and accuracy rates were 96.2% and 93.4%, respectively.

Conclusions: Mapping the SL with fluorescent dye can play an important role in the treatment of colon cancers, particularly those at early stages, and can lead to ultra-conservative surgery.

Citing Articles

Enhanced Lymph Node Detection in Colon Cancer Using Indocyanine Green Fluorescence: A Systematic Review of Studies from 2020 Onwards.

Negrut R, Cote A, Feder B, Bodog F, Maghiar A J Pers Med. 2025; 15(2).

PMID: 39997331 PMC: 11855940. DOI: 10.3390/jpm15020054.

Indocyanine green guided sentinel lymph node biopsy may have a high sensitivity for early (T1/T2) colon cancer: A prospective study in Indian patients.

Ahmed Z, Patil S, Sekaran A, Rebala P, Rao G Turk J Surg. 2023; 39(3):190-196.

PMID: 38058374 PMC: 10696441. DOI: 10.47717/turkjsurg.2023.6106.

Indocyanine green dye and its application in gastrointestinal surgery: The future is bright green.

Lim Z, Mohan S, Balasubramaniam S, Ahmed S, Siew C, Shelat V World J Gastrointest Surg. 2023; 15(9):1841-1857.

PMID: 37901741 PMC: 10600780. DOI: 10.4240/wjgs.v15.i9.1841.

Clinical Effectiveness of Fluorescence Lymph Node Mapping Using ICG for Laparoscopic Right Hemicolectomy: A Prospective Case-Control Study.

Son G, Yun M, Lee I, Im S, Kim K, Park S Cancers (Basel). 2023; 15(20).

PMID: 37894294 PMC: 10605135. DOI: 10.3390/cancers15204927.

Robot-assisted fluorescent sentinel lymph node identification in early-stage colon cancer.

Sikkenk D, Sterkenburg A, Burghgraef T, Akol H, Schwartz M, Arensman R Surg Endosc. 2023; 37(11):8394-8403.

PMID: 37721591 PMC: 10615938. DOI: 10.1007/s00464-023-10394-2.

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