Zwitterionic-to-cationic Charge Conversion Polyprodrug Nanomedicine for Enhanced Drug Delivery

Overview

Journal Theranostics

Date 2020 Jun 20

PMID 32550894

Citations 15

Authors

Sheng Wang

Fuwu Zhang

Guocan Yu

Zhantong Wang

Orit Jacobson

Ying Ma

Rui Tian

Hongzhang Deng

Weijing Yang

Zhi-Yi Chen

Xiaoyuan Chen

Affiliations

Soon will be listed here.

Abstract

Zwitterionic surface modification is a promising strategy for nanomedicines to achieve prolonged circulation time and thus effective tumor accumulation. However, zwitterion modified nanoparticles suffer from reduced cellular internalization efficiency. A polyprodrug-based nanomedicine with zwitterionic-to-cationic charge conversion ability (denoted as ZTC-NMs) was developed for enhanced chemotherapeutic drug delivery. The polyprodrug consists of pH-responsive poly(carboxybetaine)-like zwitterionic segment and glutathione-responsive camptothecin prodrug segment. The ZTC-NMs combine the advantages of zwitterionic surface and polyprodrug. Compared with conventional zwitterionic surface, the ZTC-NMs can respond to tumor microenvironment and realize ZTC surface charge conversion, thus improve cellular internalization efficiency of the nanomedicines. This ZTC method offers a strategy to promote the drug delivery efficiency and therapeutic efficacy, which is promising for the development of cancer nanomedicines.

Citing Articles

Recent Advances in the Development and Utilization of Nanoparticles for the Management of Malignant Solid Tumors.

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Recent advances in zwitterionic nanoscale drug delivery systems to overcome biological barriers.

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Bridging Smart Nanosystems with Clinically Relevant Models and Advanced Imaging for Precision Drug Delivery.

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The application of nanomedicine in clinical settings.

Zhao Q, Cheng N, Sun X, Yan L, Li W Front Bioeng Biotechnol. 2023; 11:1219054.

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pH-triggered cancer-targeting polymers: From extracellular accumulation to intracellular release.

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