Benefits of the Consumption of Brazil Nut () Extract in Male Reproductive Parameters of Streptozotocin-induced Diabetic rats

Overview

Journal J Diabetes Metab Disord

Specialty Endocrinology

Date 2020 Jun 19

PMID 32550168

Citations 1

Authors

Leonardo Parreira Silva Nascimento

Vanessa Cardoso Pires

Daniel Araki Ribeiro

Andrea Pittelli Boiago Gollucke

Hirochi Yamamura

Odair Aguiar Junior

Affiliations

Soon will be listed here.

Abstract

Objective: The objective of this study was to evaluate the effects of intake of Brazil nut extract (BN) or sodium selenite solution on reproductive parameters of male diabetic animals.

Methods: A total of 48 Wistar rats were distributed into six groups: diabetes ( = 8); diabetes and Brazil nut extract ( = 8); diabetes and sodium selenite (NaSeO) ( = 8); Brazil nut extract (n = 8); sodium selenite (n = 8) and control (n = 8). A single dose of streptozotocin (65 mg/kg) was injected intravenously to the rats to induce diabetes. BN or NaSeO were administered by gavage for 56 days.

Results: The diabetes caused critical alterations on body mass gain, reproductive parameters and antioxidant capacity. Treatments with both BN or NaSeO were able to increase significantly the glutathione peroxidase and the daily sperm production, both in diabetic ( < 0.01 and < 0.05) and in healthy animals (p < 0.01 and p < 0.05).

Conclusion: The Brazil nut extract and sodium selenite were able to improve some reproductive parameters of diabetic rats. Moreover, we could infer that this effect is probably due to the natural selenium content of the BN.

Citing Articles

Brazil nut () and metformin abrogate cardiac complication in fructose/STZ-induced type 2 diabetic rats by attenuating oxidative stress and modulating the MAPK-mTOR/NFkB/IL-10 signaling pathways.

Li Z, Wang B, Bai D, Zhang L Food Nutr Res. 2024; 68.

PMID: 39239455 PMC: 11375446. DOI: 10.29219/fnr.v68.10749.

References

Barceloux D . Selenium. J Toxicol Clin Toxicol. 1999; 37(2):145-72. DOI: 10.1081/clt-100102417. View

Masaki H, Okano Y, Sakurai H . Differential role of catalase and glutathione peroxidase in cultured human fibroblasts under exposure of H2O2 or ultraviolet B light. Arch Dermatol Res. 1998; 290(3):113-8. DOI: 10.1007/s004030050275. View

Chougala M, Bhaskar J, Rajan M, Salimath P . Effect of curcumin and quercetin on lysosomal enzyme activities in streptozotocin-induced diabetic rats. Clin Nutr. 2012; 31(5):749-55. DOI: 10.1016/j.clnu.2012.02.003. View

Chowdhury A, Tcholakian R . Effects of various doses of testosterone propionate on intratesticular and plasma testosterone levels and maintenance of spermatogenesis in adult hypophysectomized rats. Steroids. 1979; 34(2):151-62. DOI: 10.1016/0039-128x(79)90044-8. View

Walker W . Molecular mechanisms of testosterone action in spermatogenesis. Steroids. 2008; 74(7):602-7. DOI: 10.1016/j.steroids.2008.11.017. View

Ricci G, Catizone A, Esposito R, Pisanti F, Vietri M, Galdieri M . Diabetic rat testes: morphological and functional alterations. Andrologia. 2009; 41(6):361-8. DOI: 10.1111/j.1439-0272.2009.00937.x. View

Saaranen M, Suistomaa U, Kantola M, Saarikoski S, VANHA-PERTTULA T . Lead, magnesium, selenium and zinc in human seminal fluid: comparison with semen parameters and fertility. Hum Reprod. 1987; 2(6):475-9. DOI: 10.1093/oxfordjournals.humrep.a136573. View

Singh S, Malini T, Rengarajan S, Balasubramanian K . Impact of experimental diabetes and insulin replacement on epididymal secretory products and sperm maturation in albino rats. J Cell Biochem. 2009; 108(5):1094-101. DOI: 10.1002/jcb.22337. View

Hei Y, Farahbakhshian S, Chen X, Battell M, McNeill J . Stimulation of MAP kinase and S6 kinase by vanadium and selenium in rat adipocytes. Mol Cell Biochem. 1998; 178(1-2):367-75. DOI: 10.1023/a:1006819906820. View

10.

Maritim A, Sanders R, Watkins 3rd J . Diabetes, oxidative stress, and antioxidants: a review. J Biochem Mol Toxicol. 2003; 17(1):24-38. DOI: 10.1002/jbt.10058. View

11.

Castro A, Berndtson W, Cardoso F . Plasma and testicular testosterone levels, volume density and number of Leydig cells and spermatogenic efficiency of rabbits. Braz J Med Biol Res. 2002; 35(4):493-8. DOI: 10.1590/s0100-879x2002000400014. View

12.

Vehik K, Dabelea D . The changing epidemiology of type 1 diabetes: why is it going through the roof?. Diabetes Metab Res Rev. 2011; 27(1):3-13. DOI: 10.1002/dmrr.1141. View

13.

Unlucerci Y, Bekpinar S, Kocak H . Testis glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase activities in aminoguanidine-treated diabetic rats. Arch Biochem Biophys. 2000; 379(2):217-20. DOI: 10.1006/abbi.2000.1876. View

14.

Zirkin B, Santulli R, Awoniyi C, EWING L . Maintenance of advanced spermatogenic cells in the adult rat testis: quantitative relationship to testosterone concentration within the testis. Endocrinology. 1989; 124(6):3043-9. DOI: 10.1210/endo-124-6-3043. View

15.

Guneli E, Tugyan K, Ozturk H, Gumustekin M, Cilaker S, Uysal N . Effect of melatonin on testicular damage in streptozotocin-induced diabetes rats. Eur Surg Res. 2008; 40(4):354-60. DOI: 10.1159/000118032. View

16.

Ahmed O, Gabar M, Ali T . Impacts of the coexistence of diabetes and hypothyroidism on body weight gain, leptin and various metabolic aspects in albino rats. J Diabetes Complications. 2012; 26(6):491-500. DOI: 10.1016/j.jdiacomp.2012.05.021. View

17.

Agarwal A, Prabakaran S, Said T . Prevention of oxidative stress injury to sperm. J Androl. 2005; 26(6):654-60. DOI: 10.2164/jandrol.05016. View

18.

Coviello A, Bremner W, Matsumoto A, Herbst K, Amory J, Anawalt B . Intratesticular testosterone concentrations comparable with serum levels are not sufficient to maintain normal sperm production in men receiving a hormonal contraceptive regimen. J Androl. 2004; 25(6):931-8. DOI: 10.1002/j.1939-4640.2004.tb03164.x. View

19.

Luo L, Chen H, Trush M, Show M, Anway M, Zirkin B . Aging and the brown Norway rat leydig cell antioxidant defense system. J Androl. 2005; 27(2):240-7. DOI: 10.2164/jandrol.05075. View

20.

Ayaz M, Can B, Ozdemir S, Turan B . Protective effect of selenium treatment on diabetes-induced myocardial structural alterations. Biol Trace Elem Res. 2002; 89(3):215-26. DOI: 10.1385/bter:89:3:215. View