The Relationship Between Sex Steroids, Insulin Resistance and Body Compositions in Obese Women: A Case-control Study

Overview

Journal J Med Biochem

Specialty Biochemistry

Date 2020 Jun 19

PMID 32549774

Citations 7

Authors

Seher Sayin

Ruhusen Kutlu

Mustafa Kulaksizoglu

Affiliations

Soon will be listed here.

Abstract

Background: Obesity causes many health problems and affects the quality and duration of life negatively. We aimed to investigate the relationship between sex steroids, insulin resistance and body compositions in obese women.

Methods: This study was carried out on a sample of 150 premenopausal women who were referred to the Outpatient Clinic of Family Medicine between 2014-2015. A survey about their socio-demographic characteristics was carried out, and anthropometric parameters were measured. LDL-C, HDL-C, total cholesterol, triglyceride, glucose, insulin, sex hormone binding globulin (SHBG), estradiol, dehydroepiandrosterone sulfate (DHEA-S), total/free testosterone levels were measured in the blood. Body compositions were assessed with a bioelectrical impedance device. For insulin resistance, Homeostasis Model Assessment (HOMA-IR) was calculated.

Results: In our study, a significant association was found between high glucose, total cholesterol, LDL-C, TG, insulin, insulin resistance and low HDL-C, SHBG, DHEA-S levels with obesity (p<0.05). There was no statistically significant relationship between estradiol, total/free testosterone and obesity (p>0.05).

Conclusions: In our study, high glucose, total cholesterol, LDL-c, TG, insulin, insulin resistance and low HDL-C, SHBG, DHEA-S levels were associated with obesity. This relationship leads to many diseases, especially diabetes mellitus and cardiovascular disease. Therefore, obesity is a disease that needs to be monitored closely, frequently and treated properly.

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References

Abbasi F, Brown Jr B, Lamendola C, McLaughlin T, Reaven G . Relationship between obesity, insulin resistance, and coronary heart disease risk. J Am Coll Cardiol. 2002; 40(5):937-43. DOI: 10.1016/s0735-1097(02)02051-x. View

Ogden C, Carroll M, Flegal K . Epidemiologic trends in overweight and obesity. Endocrinol Metab Clin North Am. 2004; 32(4):741-60, vii. DOI: 10.1016/s0889-8529(03)00074-4. View

. Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee. World Health Organ Tech Rep Ser. 1995; 854:1-452. View

Matsubara M, Maruoka S, Katayose S . Inverse relationship between plasma adiponectin and leptin concentrations in normal-weight and obese women. Eur J Endocrinol. 2002; 147(2):173-80. DOI: 10.1530/eje.0.1470173. View

Perry A, Wang X, Goldberg R, Ross R, Jackson L . Androgenic sex steroids contribute to metabolic risk beyond intra-abdominal fat in overweight/obese black and white women. Obesity (Silver Spring). 2013; 21(8):1618-24. DOI: 10.1002/oby.20204. View

Hernandez-Morante J, Milagro F, Gabaldon J, Martinez J, Zamora S, Garaulet M . Effect of DHEA-sulfate on adiponectin gene expression in adipose tissue from different fat depots in morbidly obese humans. Eur J Endocrinol. 2006; 155(4):593-600. DOI: 10.1530/eje.1.02256. View

Garcia-Alvarez A, Serra-Majem L, Ribas-Barba L, Castell C, Foz M, Uauy R . Obesity and overweight trends in Catalonia, Spain (1992-2003): gender and socio-economic determinants. Public Health Nutr. 2007; 10(11A):1368-78. DOI: 10.1017/S1368980007000973. View

Pasquali R . Obesity and androgens: facts and perspectives. Fertil Steril. 2006; 85(5):1319-40. DOI: 10.1016/j.fertnstert.2005.10.054. View

Phillips G, Jing T, Heymsfield S . Does insulin resistance, visceral adiposity, or a sex hormone alteration underlie the metabolic syndrome? Studies in women. Metabolism. 2008; 57(6):838-44. PMC: 2507726. DOI: 10.1016/j.metabol.2008.01.029. View

10.

Damiati S . Serum Levels of Asymmetric and Symmetric Dimethylarginine in Women with Vitamin D Deficiency and History of Pregnancy Loss - A Pilot Study. J Med Biochem. 2018; 37(4):441-447. PMC: 6298471. DOI: 10.1515/jomb-2017-0069. View

11.

Satman I, Yilmaz T, Sengul A, Salman S, Salman F, Uygur S . Population-based study of diabetes and risk characteristics in Turkey: results of the turkish diabetes epidemiology study (TURDEP). Diabetes Care. 2002; 25(9):1551-6. DOI: 10.2337/diacare.25.9.1551. View

12.

Al-Harithy R . Dehydroepiandrosterone sulfate levels in women. Relationships with body mass index, insulin and glucose levels. Saudi Med J. 2003; 24(8):837-41. View

13.

Blagojevic I, Ignjatovic S, Macut D, Kotur-Stevuljevic J, Bozic-Antic I, Vekic J . Evaluation of a Summary Score for Dyslipidemia, Oxidative Stress and Inflammation (the Doi Score) in Women with Polycystic Ovary Syndrome and its Relationship with Obesity. J Med Biochem. 2018; 37(4):476-485. PMC: 6298479. DOI: 10.2478/jomb-2018-0008. View

14.

Jaff N, Norris S, Snyman T, Toman M, Crowther N . Body composition in the Study of Women Entering and in Endocrine Transition (SWEET): A perspective of African women who have a high prevalence of obesity and HIV infection. Metabolism. 2015; 64(9):1031-41. DOI: 10.1016/j.metabol.2015.05.009. View

15.

Svensson H, Wetterling L, Bosaeus M, Oden B, Oden A, Jennische E . Body fat mass and the proportion of very large adipocytes in pregnant women are associated with gestational insulin resistance. Int J Obes (Lond). 2015; 40(4):646-53. PMC: 4827013. DOI: 10.1038/ijo.2015.232. View

16.

Gomez-Santos C, Hernandez-Morante J, Tebar F, Granero E, Garaulet M . Differential effect of oral dehydroepiandrosterone-sulphate on metabolic syndrome features in pre- and postmenopausal obese women. Clin Endocrinol (Oxf). 2011; 77(4):548-54. DOI: 10.1111/j.1365-2265.2011.04306.x. View

17.

Bonnet F, Balkau B, Malecot J, Picard P, Lange C, Fumeron F . Sex hormone-binding globulin predicts the incidence of hyperglycemia in women: interactions with adiponectin levels. Eur J Endocrinol. 2009; 161(1):81-5. DOI: 10.1530/EJE-09-0202. View

18.

Bakhshi E, Eshraghian M, Mohammad K, Rahimi Foroushani A, Zeraati H, Fotouhi A . Sociodemographic and smoking associated with obesity in adult women in Iran: results from the National Health Survey. J Public Health (Oxf). 2008; 30(4):429-35. DOI: 10.1093/pubmed/fdn024. View

19.

Kahn S, Hull R, Utzschneider K . Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature. 2006; 444(7121):840-6. DOI: 10.1038/nature05482. View

20.

. Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser. 2001; 894:i-xii, 1-253. View