How DNA Methylation Affects the Warburg Effect

Overview

Journal Int J Biol Sci

Specialty Biology

Date 2020 Jun 19

PMID 32549751

Citations 16

Authors

Xingxin Zhu

Zefeng Xuan

Jun Chen

Zequn Li

Shusen Zheng

Penghong Song

Affiliations

Soon will be listed here.

Abstract

Significant enhancement of the glycolysis pathway is a major feature of tumor cells, even in the presence of abundant oxygen; this enhancement is known as the Warburg effect, and also called aerobic glycolysis. The Warburg effect was discovered nearly a hundred years ago, but its specific mechanism remains difficult to explain. DNA methylation is considered to be a potential trigger for the Warburg effect, as the two processes have many overlapping links during tumorigenesis. Based on a widely recognized potential mechanism of the Warburg effect, we here summarized the relationship between DNA methylation and the Warburg effect with regard to cellular energy metabolism factors, such as glycolysis related enzymes, mitochondrial function, glycolysis bypass pathways, the tumor oxygen sensing pathway and abnormal methylation conditions. We believe that clarifying the relationship between these different mechanisms may further help us understand how DNA methylation works on tumorigenesis and provide new opportunities for cancer therapy.

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