Panaxynol, a Bioactive Component of American Ginseng, Targets Macrophages and Suppresses Colitis in Mice

Overview

Journal Oncotarget

Specialty Oncology

Date 2020 Jun 18

PMID 32547701

Citations 11

Authors

Anusha Chaparala

Deepak Poudyal

Hossam Tashkandi

Erin E Witalison

Alexander A Chumanevich

Jenna L Hofseth

Ivy Nguyen

Olivia Hardy

Douglas L Pittman

Michael D Wyatt

Anthony Windust

Elizabeth A Murphy

Mitzi Nagarkatti

Prakash Nagarkatti

Lorne J Hofseth

Affiliations

Soon will be listed here.

Abstract

Ulcerative colitis has a significant impact on the quality of life for the patients, and can substantially increase the risk of colon cancer in patients suffering long-term. Conventional treatments provide only modest relief paired with a high risk of side effects, while complementary and alternative medicines can offer safe and effective options. Over the past decade, we have shown that both American ginseng and its hexane fraction (HAG) have anti-oxidant and anti-inflammatory properties that can suppress mouse colitis and prevent colitis-associated colon cancer. With the goal of isolating a single active compound, we further fractionated HAG, and found the most abundant molecule in this fraction was the polyacetylene, panaxynol (PA). After isolating and characterizing PA, we tested the efficacy of PA in the treatment and prevention of colitis in mice and studied the mechanism of action. We demonstrate here that PA effectively treats colitis in a Dextran Sulfate Sodium mouse model by targeting macrophages for DNA damage and apoptosis. This study provides additional mechanistic evidence that American ginseng can be used for conventional treatment of colitis and other diseases associated with macrophage dysfunction.

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