Coexisting Diseases in Patients with Familial Mediterranean Fever

Overview

Journal Open Access Rheumatol

Publisher Dove Medical Press

Specialty Rheumatology

Date 2020 Jun 18

PMID 32547265

Citations 5

Authors

Farhad Salehzadeh

Afsaneh Enteshari Moghaddam

Affiliations

Soon will be listed here.

Abstract

Background And Aims: Familial Mediterranean fever (FMF) is a prototype of autoinflammatory disease and mainly associated with gene mutations. This single-center study as an experience represents FMF-coexisting disease in the FMF registration database.

Methods: Four hundred patients who had FMF based on clinical criteria (Tel-Hashomer) and/or mutations enrolled the study. Twelve most common mutations (P369S, F479L, M680I (G/C), M680I (G/A), I692del, M694V, M694I, K695R, V726A, A744S, R761H, E148Q) were analyzed if needed by the reverse hybridization assay. Any co-existed disease had been confirmed by a related subspecialist. All data were analyzed by a simple analytical method.

Results: Fifty-seven (14%) patients had associated disease, 32 patients were male and 24 patients were under 10 years old. They included 92 variant alleles and only in five patients there were not any mutations. The most common variant alleles were (36%), (22%), (17%), (1%) and M694I (0.07%) respectively. Rheumatologic disorders were the most common coexisting disease, then followed by gastrointestinal and neurological disorders. Some rare diseases such as TTP, growth hormone deficiency, multiple sclerosis, idiopathic ascites, Leiden factor V deficiency and Felty syndrome have been detected. Homozygote mutations of () were associated with idiopathic ascites, orchitis and pericarditis.

Conclusion: Coexisting disease in patients with FMF is presented with positive gene mutations particularly with these five common variant alleles: , and . The commonly associated diseases are rheumatologic, gastrointestinal and CNS disorders.

Citing Articles

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Dermatological Comorbidities in Patients with Familiar Mediterranean Fever.

Magen E, Ozeri D, Merzon E, Vinker S, Israel A Acta Derm Venereol. 2024; 104:adv39988.

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Familial Mediterranean fever in Armenian children with inflammatory bowel disease.

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Flouda S, Moysidou G, Damoulari C, Kapsala N, Kosmetatou M, Antoniadou A Mediterr J Rheumatol. 2022; 33(2):252-255.

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Neurological Face of Familial Mediterranean Fever.

Bektas P, Kavas Tufan A, Cetin N, Yarar C, Carman K Turk Arch Pediatr. 2022; 57(5):511-515.

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