Extract of Synergizes with Cisplatin to Inhibit Oral Cancer Cell Growth Via Repression of Cell Cycle Progression and Activation of the Caspase Cascade

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2020 Jun 18

PMID 32545807

Citations 3

Authors

Xiao-Fan Huang

Kai-Fu Chang

Shan-Chih Lee

Chia-Yu Li

Hung-Hsiu Liao

Ming-Chang Hsieh

Nu-Man Tsai

Affiliations

Soon will be listed here.

Abstract

Oral cancer-a type of head and neck cancer-is estimated to be the fifth most common cancer in Taiwan. However, efficacious therapies for oral cancer are still lacking due to drug resistance and recurrence. Consequently, the identification of new anticancer agents for clinical treatment is needed. is a plant of the genus often used as a treatment in traditional medicine due to its anti-inflammatory, antibacterial and diuretic functions. The biofunctions of including its anticancer potential, have not been fully explored. As a result, the aim of this research was to investigate the anticancer activity of extract (JIB extract) and determine whether JIB extract has synergistic effects with cisplatin in oral cancer. These results are the first to demonstrate that JIB extract exhibits anticancer capacity and synergizes with cisplatin to treat oral cancer. Our findings indicate that JIB extract has a potential to develop anticancer agent and chemo therapeutic adjuvant for oral cancer.

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