The Correlations Between Th1 and Th2 Cytokines in Human Alveolar Echinococcosis

Overview

Journal BMC Infect Dis

Publisher Biomed Central

Specialty Infectious Diseases

Date 2020 Jun 17

PMID 32539714

Citations 5

Authors

Xiao Ma

Xuefei Zhang

Jia Liu

Yufang Liu

Cunzhe Zhao

Huixia Cai

Wen Lei

Junying Ma

Haining Fan

Jianye Zhou

Na Liu

Jingxiao Zhang

Yongshun Wang

Wei Wang

Peizhen Zhan

Xiongying Zhang

Qing Zhang

Kemei Shi

Peiyun Liu

Affiliations

Soon will be listed here.

Abstract

Background: Alveolar echinococcosis (AE) is a zoonotic parasitic disease caused by Echinococcus multilocularis larval tapeworm infections in humans that severely impairs the health of affected patients in the northern hemisphere.

Methods: The expression levels of 20 cytokines associated with AE infection were measured by enzyme-linked immunosorbent assay, and the correlations between these cytokines were analysed in the R programming language.

Results: Serum cytokine levels differed among individuals in both the AE patient and healthy control groups. The results of the correlations among the cytokines showed obvious differences between the two groups. In the AE patients group, Th1 and Th2 cytokines formed a more complicated network than that in the healthy control group.

Conclusions: The altered correlations between Th1 and Th2 cytokines may be closely associated with AE infection, which may provide a new explanation for the essential differences between AE patients and healthy individuals.

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