MicroRNA-892a Regulates Laryngocarcinoma Cell Proliferation Via Dicer

Overview

Journal Exp Biol Med (Maywood)

Specialty Biology

Date 2020 Jun 16

PMID 32536202

Citations 4

Authors

Jinhui Dong

Jianxing Wang

Chunguang Shan

Haizhong Zhang

Ou Xu

Affiliations

Soon will be listed here.

Abstract

This work expanded the knowledge of the molecular mechanisms underlying LC progression by exploring the role of miR-892a in the viability of TU212 and M4E cells. The results showed that miR-892a, which exhibited elevated expression in LC cells and tissue specimens of patients with LC, exerted an inhibitory effect on Dicer expression, whereas silencing of miR-892a in TU212 and M4E cells hindered cell proliferation and growth and promoted apoptosis. Furthermore, miR-892a was demonstrated to directly target Dicer 3'-UTR and inhibit its expression. These findings demonstrated that miR-892a acted as an LC oncogene via its action on Dicer, which further confirmed that miR-892a can serve as a diagnostic indicator or promising agent for LC treatment.

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