Genetic Variants of VDR and CYP2R1 Affect BMI Independently of Serum Vitamin D Concentrations

Overview

Journal BMC Med Genet

Publisher Biomed Central

Specialty Genetics

Date 2020 Jun 15

PMID 32534577

Citations 5

Authors

Bence Bakos

Balazs Szili

Boglarka Szabo

Peter Horvath

Gyongyi Kirschner

Janos P Kosa

Erzsebet Toldy

Peter Lakatos

Adam G Tabak

Istvan Takacs

Affiliations

Soon will be listed here.

Abstract

Background: Vitamin D metabolism and obesity have been linked by several studies, however the reason for this association is unclear. Our objective was to investigate potential correlations between genetic variants in key enzymes of vitamin D metabolism and the body mass index on a representative and random sample of Hungarian adults.

Methods: Altogether 462 severely vitamin D deficient individuals were studied at the end of winter in order to decrease environmental and maximize any relevant genetic effect. Furthermore, participants with lifestyle factors known to affect vitamin D homeostasis were also excluded. We selected 23 target SNPs in five genes that encode key proteins of vitamin D metabolism (NADSYN1, GC, CYP24A1, CYP2R1, VDR).

Results: Variants in 2 genetic polymorphisms; rs2853564 (VDR) and rs11023374 (CYP2R1) showed a significant association with participants' BMI. These associations survived further adjustment for total-, free-, or bioactive-25(OH) vitamin D levels, although the variance explained by these 2 SNPS in BMI heterogeneity was only 3.2%.

Conclusion: Our results show two novel examples of the relationship between genetics of vitamin D and BMI, highlighting the potential role of vitamin D hormone in the physiology of obesity.

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