Long Non-coding RNAs Involved in Pathogenic Infection

Overview

Journal Front Genet

Date 2020 Jun 13

PMID 32528521

Citations 23

Authors

Shintaro Shirahama

Atsuko Miki

Toshikatsu Kaburaki

Nobuyoshi Akimitsu

Affiliations

Soon will be listed here.

Abstract

Recently developed technologies have revealed that the genomes of many organisms produce transcripts that do not encode proteins. These are called non-coding RNAs. Long non-coding RNAs (lncRNAs) are important regulators of the expression of their target genes at the levels of transcription, translation, and degradation. Multiple studies have demonstrated a role for lncRNAs in various biological responses, including pathogenic infection. Upon pathogenic infection, the expression levels of lncRNAs are dynamically altered, suggesting that lncRNAs are involved in the host immune response or propagation of pathogens. In this review, we focused on host lncRNAs that are involved in pathogenic infection. Some host lncRNAs act as host defense molecules to prevent pathogenic proliferation, while others are utilized by the pathogen to enhance the propagation of pathogens.

Citing Articles

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References

Mogensen T . Pathogen recognition and inflammatory signaling in innate immune defenses. Clin Microbiol Rev. 2009; 22(2):240-73, Table of Contents. PMC: 2668232. DOI: 10.1128/CMR.00046-08. View

Ouyang J, Zhu X, Chen Y, Wei H, Chen Q, Chi X . NRAV, a long noncoding RNA, modulates antiviral responses through suppression of interferon-stimulated gene transcription. Cell Host Microbe. 2014; 16(5):616-26. PMC: 7104942. DOI: 10.1016/j.chom.2014.10.001. View

Gomez J, Wapinski O, Yang Y, Bureau J, Gopinath S, Monack D . The NeST long ncRNA controls microbial susceptibility and epigenetic activation of the interferon-γ locus. Cell. 2013; 152(4):743-54. PMC: 3577098. DOI: 10.1016/j.cell.2013.01.015. View

Schneider C, King R, Philipson L . Genes specifically expressed at growth arrest of mammalian cells. Cell. 1988; 54(6):787-93. DOI: 10.1016/s0092-8674(88)91065-3. View

IIott N, Heward J, Roux B, Tsitsiou E, Fenwick P, Lenzi L . Long non-coding RNAs and enhancer RNAs regulate the lipopolysaccharide-induced inflammatory response in human monocytes. Nat Commun. 2014; 5:3979. PMC: 4061460. DOI: 10.1038/ncomms4979. View

Carpenter S, Aiello D, Atianand M, Ricci E, Gandhi P, Hall L . A long noncoding RNA mediates both activation and repression of immune response genes. Science. 2013; 341(6147):789-92. PMC: 4376668. DOI: 10.1126/science.1240925. View

Bruscella P, Bottini S, Baudesson C, Pawlotsky J, Feray C, Trabucchi M . Viruses and miRNAs: More Friends than Foes. Front Microbiol. 2017; 8:824. PMC: 5430039. DOI: 10.3389/fmicb.2017.00824. View

Lefevre P, Witham J, Lacroix C, Cockerill P, Bonifer C . The LPS-induced transcriptional upregulation of the chicken lysozyme locus involves CTCF eviction and noncoding RNA transcription. Mol Cell. 2008; 32(1):129-39. PMC: 2581490. DOI: 10.1016/j.molcel.2008.07.023. View

Wang J, Wang Y, Zhou R, Zhao J, Zhang Y, Yi D . Host Long Noncoding RNA lncRNA-PAAN Regulates the Replication of Influenza A Virus. Viruses. 2018; 10(6). PMC: 6024364. DOI: 10.3390/v10060330. View

10.

de Chassey B, Navratil V, Tafforeau L, Hiet M, Aublin-Gex A, Agaugue S . Hepatitis C virus infection protein network. Mol Syst Biol. 2008; 4:230. PMC: 2600670. DOI: 10.1038/msb.2008.66. View

11.

Carnero E, Barriocanal M, Prior C, Unfried J, Segura V, Guruceaga E . Long noncoding RNA EGOT negatively affects the antiviral response and favors HCV replication. EMBO Rep. 2016; 17(7):1013-28. PMC: 4931568. DOI: 10.15252/embr.201541763. View

12.

Vigneau S, Levillayer F, Crespeau H, Cattolico L, Caudron B, Bihl F . Homology between a 173-kb region from mouse chromosome 10, telomeric to the Ifng locus, and human chromosome 12q15. Genomics. 2001; 78(3):206-13. DOI: 10.1006/geno.2001.6656. View

13.

Wang Z, Fan P, Zhao Y, Zhang S, Lu J, Xie W . NEAT1 modulates herpes simplex virus-1 replication by regulating viral gene transcription. Cell Mol Life Sci. 2016; 74(6):1117-1131. PMC: 5309293. DOI: 10.1007/s00018-016-2398-4. View

14.

Winterling C, Koch M, Koeppel M, Garcia-Alcalde F, Karlas A, Meyer T . Evidence for a crucial role of a host non-coding RNA in influenza A virus replication. RNA Biol. 2014; 11(1):66-75. PMC: 3929426. DOI: 10.4161/rna.27504. View

15.

Skalsky R, Cullen B . Viruses, microRNAs, and host interactions. Annu Rev Microbiol. 2010; 64:123-41. PMC: 3621958. DOI: 10.1146/annurev.micro.112408.134243. View

16.

Wang Y, Zhong H, Xie X, Chen C, Huang D, Shen L . Long noncoding RNA derived from CD244 signaling epigenetically controls CD8+ T-cell immune responses in tuberculosis infection. Proc Natl Acad Sci U S A. 2015; 112(29):E3883-92. PMC: 4517270. DOI: 10.1073/pnas.1501662112. View

17.

Yang R, Huang F, Fu J, Dou B, Xu B, Miao L . Differential transcription profiles of long non-coding RNAs in primary human brain microvascular endothelial cells in response to meningitic Escherichia coli. Sci Rep. 2016; 6:38903. PMC: 5153642. DOI: 10.1038/srep38903. View

18.

Nishitsuji H, Ujino S, Yoshio S, Sugiyama M, Mizokami M, Kanto T . Long noncoding RNA #32 contributes to antiviral responses by controlling interferon-stimulated gene expression. Proc Natl Acad Sci U S A. 2016; 113(37):10388-93. PMC: 5027408. DOI: 10.1073/pnas.1525022113. View

19.

Wyler E, Menegatti J, Franke V, Kocks C, Boltengagen A, Hennig T . Widespread activation of antisense transcription of the host genome during herpes simplex virus 1 infection. Genome Biol. 2017; 18(1):209. PMC: 5663069. DOI: 10.1186/s13059-017-1329-5. View

20.

Dias A, Bouvier D, Crepin T, McCarthy A, Hart D, Baudin F . The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit. Nature. 2009; 458(7240):914-8. DOI: 10.1038/nature07745. View