Transposable Elements, Circular RNAs and Mitochondrial Transcription in Age-related Genomic Regulation

Overview

Journal Development

Specialty Biology

Date 2020 Jun 13

PMID 32527937

Citations 19

Authors

Juan I Bravo

Severine Nozownik

Prakroothi S Danthi

Berenice A Benayoun

Affiliations

Soon will be listed here.

Abstract

Our understanding of the molecular regulation of aging and age-related diseases is still in its infancy, requiring in-depth characterization of the molecular landscape shaping these complex phenotypes. Emerging classes of molecules with promise as aging modulators include transposable elements, circRNAs and the mitochondrial transcriptome. Analytical complexity means that these molecules are often overlooked, even though they exhibit strong associations with aging and, in some cases, may directly contribute to its progress. Here, we review the links between these novel factors and age-related phenotypes, and we suggest tools that can be easily incorporated into existing pipelines to better understand the aging process.

Citing Articles

Multi-ancestry GWAS reveals loci linked to human variation in LINE-1- and Alu-insertion numbers.

Bravo J, Zhang L, Benayoun B Transl Med Aging. 2025; 9:25-40.

PMID: 40051556 PMC: 11883834. DOI: 10.1016/j.tma.2025.02.001.

Role of circular RNAs in DNA repair.

Lagunas-Rangel F RNA Biol. 2024; 21(1):149-161.

PMID: 39550713 PMC: 11572198. DOI: 10.1080/15476286.2024.2429945.

Multi-ancestry GWAS reveals loci linked to human variation in LINE-1- and Alu-insertion numbers.

Bravo J, Zhang L, Benayoun B bioRxiv. 2024; .

PMID: 39314493 PMC: 11419044. DOI: 10.1101/2024.09.10.612283.

An eQTL-based approach reveals candidate regulators of LINE-1 RNA levels in lymphoblastoid cells.

Bravo J, Mizrahi C, Kim S, Zhang L, Suh Y, Benayoun B PLoS Genet. 2024; 20(6):e1011311.

PMID: 38848448 PMC: 11189215. DOI: 10.1371/journal.pgen.1011311.

Generation of somatic structural variation as a hallmark of cellular senescence in human lung fibroblasts.

Woronzow V, Mohner J, Remane D, Zischler H Front Cell Dev Biol. 2023; 11:1274807.

PMID: 38152346 PMC: 10751365. DOI: 10.3389/fcell.2023.1274807.

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