Protective Effects of Polydatin Against Dementia-Related Disorders

Overview

Journal Curr Neuropharmacol

Publisher Bentham Science Publishers

Date 2020 Jun 12

PMID 32525774

Citations 10

Authors

Kim San Tang

Affiliations

Soon will be listed here.

Abstract

Dementia is a collection of symptoms affecting a person's cognition. Dementia is debilitating, and therefore, finding an effective treatment is of utmost importance. Resveratrol, which exhibits neuroprotective effects, has low bioavailability. However, its glucoside polydatin is more bioavailable. Here, the evidence that supports the protective role of polydatin against dementia- related diseases such as Alzheimer's disease, vascular dementia, alcohol-related dementia, and Lewy body dementias is presented. The beneficial effects of polydatin from a mechanistic perspective are specifically emphasized in this review. Future directions in this area of research are also discussed.

Citing Articles

Protective effects of polydatin amphiphilic chitosan nanocarriers against an aluminum chloride-induced model of Alzheimer's disease in rats: relevance to its anti-inflammatory and antioxidant effects.

Zarneshan S, Arkan E, Kiani A, Hosseini S, Abbaszadeh F, Fakhri S Naunyn Schmiedebergs Arch Pharmacol. 2025; .

PMID: 39786589 DOI: 10.1007/s00210-024-03696-2.

Polydatin ameliorates early brain injury after subarachnoid hemorrhage through up-regulating SIRT1 to suppress endoplasmic reticulum stress.

Han Y, Hao G, Han S, Zhu T, Dong Y, Chen L Front Pharmacol. 2024; 15:1450238.

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Insights into the transglucosylation activity of α-glucosidase from Schwanniomyces occidentalis.

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Polydatin and Nicotinamide Rescue the Cellular Phenotype of Mitochondrial Diseases by Mitochondrial Unfolded Protein Response (mtUPR) Activation.

Cilleros-Holgado P, Gomez-Fernandez D, Pinero-Perez R, Romero Dominguez J, Talaveron-Rey M, Reche-Lopez D Biomolecules. 2024; 14(5).

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Effects of polydatin from Huhuang Shaoshang Liniment on oxidative damage and inflammatory response in rats with cerebral ischemia-reperfusion.

Sha Q, Huang Y, Zhou F, Wang Y, Fang W, Li J Am J Transl Res. 2023; 15(2):995-1006.

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