Protective Effects of Polydatin Against Dementia-Related Disorders
Overview
Authors
Affiliations
Dementia is a collection of symptoms affecting a person's cognition. Dementia is debilitating, and therefore, finding an effective treatment is of utmost importance. Resveratrol, which exhibits neuroprotective effects, has low bioavailability. However, its glucoside polydatin is more bioavailable. Here, the evidence that supports the protective role of polydatin against dementia- related diseases such as Alzheimer's disease, vascular dementia, alcohol-related dementia, and Lewy body dementias is presented. The beneficial effects of polydatin from a mechanistic perspective are specifically emphasized in this review. Future directions in this area of research are also discussed.
Zarneshan S, Arkan E, Kiani A, Hosseini S, Abbaszadeh F, Fakhri S Naunyn Schmiedebergs Arch Pharmacol. 2025; .
PMID: 39786589 DOI: 10.1007/s00210-024-03696-2.
Han Y, Hao G, Han S, Zhu T, Dong Y, Chen L Front Pharmacol. 2024; 15:1450238.
PMID: 39295935 PMC: 11408241. DOI: 10.3389/fphar.2024.1450238.
Insights into the transglucosylation activity of α-glucosidase from Schwanniomyces occidentalis.
Merdzo Z, Narmontaite E, Gonzalez-Alfonso J, Poveda A, Jimenez-Barbero J, Plou F Appl Microbiol Biotechnol. 2024; 108(1):443.
PMID: 39153091 PMC: 11330417. DOI: 10.1007/s00253-024-13262-8.
Cilleros-Holgado P, Gomez-Fernandez D, Pinero-Perez R, Romero Dominguez J, Talaveron-Rey M, Reche-Lopez D Biomolecules. 2024; 14(5).
PMID: 38786005 PMC: 11118892. DOI: 10.3390/biom14050598.
Sha Q, Huang Y, Zhou F, Wang Y, Fang W, Li J Am J Transl Res. 2023; 15(2):995-1006.
PMID: 36915795 PMC: 10006806.