MicroRNA Control of B Cell Tolerance, Autoimmunity and Cancer

Overview

Journal Semin Cancer Biol

Specialty Oncology

Date 2020 Jun 12

PMID 32522353

Citations 18

Authors

Changchun Xiao

David Nemazee

Alicia Gonzalez-Martin

Affiliations

Soon will be listed here.

Abstract

Since the discovery of the first microRNA (miRNA) in 1993, thousands of miRNAs have been identified in humans and mice and many of them have been shown to control a large variety of cellular processes in different cell types including those composing the immune system. MicroRNAs regulate virtually all aspects of immune cell development, differentiation and function. Studies have shown that these molecules are involved in the maintenance of lymphocyte tolerance and, when dysregulated, promote the development of autoimmune diseases. In this review, we focus on the current knowledge about the roles of miRNAs in B cell tolerance and their contribution to autoimmunity, highlighting additional roles for some of these miRNAs in T cell tolerance. Finally, we will comment on miRNAs that promote both autoimmunity and lymphoma.

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References

Jiang S, Li C, Olive V, Lykken E, Feng F, Sevilla J . Molecular dissection of the miR-17-92 cluster's critical dual roles in promoting Th1 responses and preventing inducible Treg differentiation. Blood. 2011; 118(20):5487-97. PMC: 3217351. DOI: 10.1182/blood-2011-05-355644. View

Cui B, Chen L, Zhang S, Mraz M, Fecteau J, Yu J . MicroRNA-155 influences B-cell receptor signaling and associates with aggressive disease in chronic lymphocytic leukemia. Blood. 2014; 124(4):546-54. PMC: 4110661. DOI: 10.1182/blood-2014-03-559690. View

Xia Y, Tao J, Fang X, Xiang N, Dai X, Jin L . MicroRNA-326 Upregulates B Cell Activity and Autoantibody Production in Lupus Disease of MRL/lpr Mice. Mol Ther Nucleic Acids. 2018; 11:284-291. PMC: 5992445. DOI: 10.1016/j.omtn.2018.02.010. View

Baskerville S, Bartel D . Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes. RNA. 2005; 11(3):241-7. PMC: 1370713. DOI: 10.1261/rna.7240905. View

Bartel D . MicroRNAs: target recognition and regulatory functions. Cell. 2009; 136(2):215-33. PMC: 3794896. DOI: 10.1016/j.cell.2009.01.002. View

Linterman M, Rigby R, Wong R, Yu D, Brink R, Cannons J . Follicular helper T cells are required for systemic autoimmunity. J Exp Med. 2009; 206(3):561-76. PMC: 2699132. DOI: 10.1084/jem.20081886. View

Bernatsky S, Lee J, Rahme E . Non-Hodgkin's lymphoma--meta-analyses of the effects of corticosteroids and non-steroidal anti-inflammatories. Rheumatology (Oxford). 2006; 46(4):690-4. DOI: 10.1093/rheumatology/kel396. View

Pauley K, Cha S, Chan E . MicroRNA in autoimmunity and autoimmune diseases. J Autoimmun. 2009; 32(3-4):189-94. PMC: 2717629. DOI: 10.1016/j.jaut.2009.02.012. View

Baumjohann D, Kageyama R, Clingan J, Morar M, Patel S, de Kouchkovsky D . The microRNA cluster miR-17∼92 promotes TFH cell differentiation and represses subset-inappropriate gene expression. Nat Immunol. 2013; 14(8):840-8. PMC: 3720769. DOI: 10.1038/ni.2642. View

10.

Koralov S, Muljo S, Galler G, Krek A, Chakraborty T, Kanellopoulou C . Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage. Cell. 2008; 132(5):860-74. DOI: 10.1016/j.cell.2008.02.020. View

11.

Vigorito E, Perks K, Abreu-Goodger C, Bunting S, Xiang Z, Kohlhaas S . microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells. Immunity. 2007; 27(6):847-59. PMC: 4135426. DOI: 10.1016/j.immuni.2007.10.009. View

12.

Vinuesa C, Sanz I, Cook M . Dysregulation of germinal centres in autoimmune disease. Nat Rev Immunol. 2009; 9(12):845-57. DOI: 10.1038/nri2637. View

13.

Casciaro M, Di Salvo E, Brizzi T, Rodolico C, Gangemi S . Involvement of miR-126 in autoimmune disorders. Clin Mol Allergy. 2018; 16:11. PMC: 5930861. DOI: 10.1186/s12948-018-0089-4. View

14.

Mok Y, Schwierzeck V, Thomas D, Vigorito E, Rayner T, Jarvis L . MiR-210 is induced by Oct-2, regulates B cells, and inhibits autoantibody production. J Immunol. 2013; 191(6):3037-3048. PMC: 4162006. DOI: 10.4049/jimmunol.1301289. View

15.

Hoyer B, Manz R, Radbruch A, Hiepe F . Long-lived plasma cells and their contribution to autoimmunity. Ann N Y Acad Sci. 2005; 1050:124-33. DOI: 10.1196/annals.1313.014. View

16.

Eis P, Tam W, Sun L, Chadburn A, Li Z, Gomez M . Accumulation of miR-155 and BIC RNA in human B cell lymphomas. Proc Natl Acad Sci U S A. 2005; 102(10):3627-32. PMC: 552785. DOI: 10.1073/pnas.0500613102. View

17.

Xiao C, Rajewsky K . MicroRNA control in the immune system: basic principles. Cell. 2009; 136(1):26-36. DOI: 10.1016/j.cell.2008.12.027. View

18.

Lu L, Boldin M, Chaudhry A, Lin L, Taganov K, Hanada T . Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses. Cell. 2010; 142(6):914-29. PMC: 3049116. DOI: 10.1016/j.cell.2010.08.012. View

19.

Belver L, de Yebenes V, Ramiro A . MicroRNAs prevent the generation of autoreactive antibodies. Immunity. 2010; 33(5):713-22. PMC: 3687137. DOI: 10.1016/j.immuni.2010.11.010. View

20.

Dai R, Zhang Y, Khan D, Heid B, Caudell D, Crasta O . Identification of a common lupus disease-associated microRNA expression pattern in three different murine models of lupus. PLoS One. 2010; 5(12):e14302. PMC: 3000827. DOI: 10.1371/journal.pone.0014302. View