Signal Enhancement of Glutamine and Glutathione by Single-step Spectral Editing

Overview

Journal J Magn Reson

Publisher Elsevier

Date 2020 Jun 11

PMID 32521478

Citations 2

Authors

Li An

Maria Ferraris Araneta

Milalynn Victorino

Jun Shen

Affiliations

Soon will be listed here.

Abstract

A single-step spectral editing approach using an always-on editing pulse was proposed to enhance the signals of strongly coupled spins. Specifically, a single-step spectral editing sequence with an always-on editing pulse applied at 2.12 ppm was used to enhance glutamine (Gln) and glutathione (GSH) signals at TE = 56 ms on a 7 T scanner. Density matrix simulations demonstrated that the current method (TE = 56 ms) led to large signal enhancement of at least 61% for Gln and 51% for GSH compared to a previous single-step method (TE = 106 ms). Monte Carlo simulations showed that the current method reduced noise-originated variations by 31% for Gln and 26% for GSH compared to a previous three-step spectral editing method from which the present method was derived.

Citing Articles

Detection of C labeling of glutamate and glutamine in human brain by proton magnetic resonance spectroscopy.

An L, Li S, Ferraris Araneta M, Johnson C, Shen J Sci Rep. 2022; 12(1):8729.

PMID: 35610241 PMC: 9130156. DOI: 10.1038/s41598-022-12654-y.

Glutamine Imaging: A New Avenue for Glioma Management.

Ekici S, Nye J, Neill S, Allen J, Shu H, Fleischer C AJNR Am J Neuroradiol. 2021; 43(1):11-18.

PMID: 34737183 PMC: 8757564. DOI: 10.3174/ajnr.A7333.

References

Hurd R, Sailasuta N, Srinivasan R, Vigneron D, Pelletier D, Nelson S . Measurement of brain glutamate using TE-averaged PRESS at 3T. Magn Reson Med. 2004; 51(3):435-40. DOI: 10.1002/mrm.20007. View

Choi I, Lee P . Doubly selective multiple quantum chemical shift imaging and T(1) relaxation time measurement of glutathione (GSH) in the human brain in vivo. NMR Biomed. 2012; 26(1):28-34. PMC: 3465620. DOI: 10.1002/nbm.2815. View

Das T, Javadzadeh A, Dey A, Sabesan P, Theberge J, Radua J . Antioxidant defense in schizophrenia and bipolar disorder: A meta-analysis of MRS studies of anterior cingulate glutathione. Prog Neuropsychopharmacol Biol Psychiatry. 2018; 91:94-102. DOI: 10.1016/j.pnpbp.2018.08.006. View

Salvadore G, van der Veen J, Zhang Y, Marenco S, Machado-Vieira R, Baumann J . An investigation of amino-acid neurotransmitters as potential predictors of clinical improvement to ketamine in depression. Int J Neuropsychopharmacol. 2011; 15(8):1063-72. PMC: 3342437. DOI: 10.1017/S1461145711001593. View

Erecinska M, Silver I . Metabolism and role of glutamate in mammalian brain. Prog Neurobiol. 1990; 35(4):245-96. DOI: 10.1016/0301-0082(90)90013-7. View

Padowski J, Weaver K, Richards T, Laurino M, Samii A, Aylward E . Neurochemical correlates of caudate atrophy in Huntington's disease. Mov Disord. 2014; 29(3):327-35. PMC: 3960319. DOI: 10.1002/mds.25801. View

Zhang Y, Shen J . Simultaneous quantification of glutamate and glutamine by J-modulated spectroscopy at 3 Tesla. Magn Reson Med. 2015; 76(3):725-32. PMC: 4788985. DOI: 10.1002/mrm.25922. View

Danielsen E, Elberling T, Rasmussen A, Dock J, Hording M, Perrild H . Reduced parietooccipital white matter glutamine measured by proton magnetic resonance spectroscopy in treated graves' disease patients. J Clin Endocrinol Metab. 2008; 93(8):3192-8. DOI: 10.1210/jc.2007-2161. View

Dringen R, Brandmann M, Hohnholt M, Blumrich E . Glutathione-Dependent Detoxification Processes in Astrocytes. Neurochem Res. 2014; 40(12):2570-82. DOI: 10.1007/s11064-014-1481-1. View

10.

Natarajan S, Venneti S . Glutamine Metabolism in Brain Tumors. Cancers (Basel). 2019; 11(11). PMC: 6893651. DOI: 10.3390/cancers11111628. View

11.

Tkac I, Oz G, Adriany G, Ugurbil K, Gruetter R . In vivo 1H NMR spectroscopy of the human brain at high magnetic fields: metabolite quantification at 4T vs. 7T. Magn Reson Med. 2009; 62(4):868-79. PMC: 2843548. DOI: 10.1002/mrm.22086. View

12.

An L, Li S, Shen J . Simultaneous determination of metabolite concentrations, T and T relaxation times. Magn Reson Med. 2017; 78(6):2072-2081. PMC: 5545076. DOI: 10.1002/mrm.26612. View

13.

Klose U . In vivo proton spectroscopy in presence of eddy currents. Magn Reson Med. 1990; 14(1):26-30. DOI: 10.1002/mrm.1910140104. View

14.

Zhang Y, An L, Shen J . Fast computation of full density matrix of multispin systems for spatially localized in vivo magnetic resonance spectroscopy. Med Phys. 2017; 44(8):4169-4178. PMC: 5578626. DOI: 10.1002/mp.12375. View

15.

An L, Ferraris Araneta M, Johnson C, Shen J . Simultaneous measurement of glutamate, glutamine, GABA, and glutathione by spectral editing without subtraction. Magn Reson Med. 2018; 80(5):1776-1786. PMC: 6107387. DOI: 10.1002/mrm.27172. View

16.

Crisi G . (1)H MR Spectroscopy of Meningiomas at 3.0T: the Role of Glutamate-Glutamine Complex and Glutathione. Neuroradiol J. 2013; 24(6):846-53. DOI: 10.1177/197140091102400603. View

17.

An L, Ferraris Araneta M, Johnson C, Shen J . Effects of carrier frequency mismatch on frequency-selective spectral editing. MAGMA. 2018; 32(2):237-246. PMC: 6995993. DOI: 10.1007/s10334-018-0717-5. View

18.

Harris J, Choi I, Brooks W . Probing astrocyte metabolism in vivo: proton magnetic resonance spectroscopy in the injured and aging brain. Front Aging Neurosci. 2015; 7:202. PMC: 4623195. DOI: 10.3389/fnagi.2015.00202. View

19.

An L, van der Veen J, Li S, Thomasson D, Shen J . Combination of multichannel single-voxel MRS signals using generalized least squares. J Magn Reson Imaging. 2012; 37(6):1445-50. PMC: 3582859. DOI: 10.1002/jmri.23941. View

20.

Yuksel C, Ongur D . Magnetic resonance spectroscopy studies of glutamate-related abnormalities in mood disorders. Biol Psychiatry. 2010; 68(9):785-94. PMC: 2955841. DOI: 10.1016/j.biopsych.2010.06.016. View