SARS-CoV-2 (Covid-19): Interferon-epsilon May Be Responsible of Decreased Mortality in Females

Overview

Journal J Reprod Immunol

Specialty Allergy & Immunology

Date 2020 Jun 11

PMID 32521376

Citations 4

Authors

Cigdem Usul Afsar

Selim Afsar

Affiliations

Soon will be listed here.

Citing Articles

Time to recovery and its determinant factors among patients with COVID-19 in Assosa COVID-19 treatment center, Western Ethiopia.

Kassie M, Gobena M, Alemu Y, Tegegne A Pneumonia (Nathan). 2023; 15(1):17.

PMID: 37925445 PMC: 10625712. DOI: 10.1186/s41479-023-00119-3.

The regulation of antiviral activity of interferon epsilon.

Zhao F, Wang W, Zheng Q, Zhang Y, Chen J Front Microbiol. 2022; 13:1006481.

PMID: 36386666 PMC: 9642105. DOI: 10.3389/fmicb.2022.1006481.

Interferon Epsilon Signaling Confers Attenuated Zika Replication in Human Vaginal Epithelial Cells.

Mungin Jr J, Chen X, Liu B Pathogens. 2022; 11(8).

PMID: 36014974 PMC: 9415962. DOI: 10.3390/pathogens11080853.

Increased mRNA Levels of , , and in Peripheral Blood Cells Are Present in Patients with Obesity and May Predict Severe COVID-19 Evolution.

Pomar C, Bonet M, Ferre-Beltran A, Fraile-Ribot P, Garcia-Gasalla M, Riera M Biomedicines. 2022; 10(8).

PMID: 36009555 PMC: 9406212. DOI: 10.3390/biomedicines10082007.

References

Zhang T, Wu Q, Zhang Z . Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak. Curr Biol. 2020; 30(8):1578. PMC: 7169893. DOI: 10.1016/j.cub.2020.03.063. View

Li S, Gong M, Zhao F, Shao J, Xie Y, Zhang Y . Type I Interferons: Distinct Biological Activities and Current Applications for Viral Infection. Cell Physiol Biochem. 2018; 51(5):2377-2396. DOI: 10.1159/000495897. View

Grasselli G, Zangrillo A, Zanella A, Antonelli M, Cabrini L, Castelli A . Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy. JAMA. 2020; 323(16):1574-1581. PMC: 7136855. DOI: 10.1001/jama.2020.5394. View

Wang Z, Xu X . scRNA-seq Profiling of Human Testes Reveals the Presence of the ACE2 Receptor, A Target for SARS-CoV-2 Infection in Spermatogonia, Leydig and Sertoli Cells. Cells. 2020; 9(4). PMC: 7226809. DOI: 10.3390/cells9040920. View

Guan W, Ni Z, Hu Y, Liang W, Ou C, He J . Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020; 382(18):1708-1720. PMC: 7092819. DOI: 10.1056/NEJMoa2002032. View

Zwarthoff E, Mooren A, Trapman J . Organization, structure and expression of murine interferon alpha genes. Nucleic Acids Res. 1985; 13(3):791-804. PMC: 341035. DOI: 10.1093/nar/13.3.791. View

Frieman M, Baric R . Mechanisms of severe acute respiratory syndrome pathogenesis and innate immunomodulation. Microbiol Mol Biol Rev. 2008; 72(4):672-85, Table of Contents. PMC: 2593566. DOI: 10.1128/MMBR.00015-08. View

Livingston E, Bucher K . Coronavirus Disease 2019 (COVID-19) in Italy. JAMA. 2020; 323(14):1335. DOI: 10.1001/jama.2020.4344. View

Ye Q, Wang B, Mao J . The pathogenesis and treatment of the `Cytokine Storm' in COVID-19. J Infect. 2020; 80(6):607-613. PMC: 7194613. DOI: 10.1016/j.jinf.2020.03.037. View

10.

Sharma G, Volgman A, Michos E . Sex Differences in Mortality From COVID-19 Pandemic: Are Men Vulnerable and Women Protected?. JACC Case Rep. 2020; 2(9):1407-1410. PMC: 7198137. DOI: 10.1016/j.jaccas.2020.04.027. View

11.

Fung K, Mangan N, Cumming H, Horvat J, Mayall J, Stifter S . Interferon-ε protects the female reproductive tract from viral and bacterial infection. Science. 2013; 339(6123):1088-92. PMC: 3617553. DOI: 10.1126/science.1233321. View

12.

Ahn D, Shin H, Kim M, Lee S, Kim H, Myoung J . Current Status of Epidemiology, Diagnosis, Therapeutics, and Vaccines for Novel Coronavirus Disease 2019 (COVID-19). J Microbiol Biotechnol. 2020; 30(3):313-324. PMC: 9728410. DOI: 10.4014/jmb.2003.03011. View

13.

Marks Z, Campbell N, deWeerd N, Lim S, Gearing L, Bourke N . PROPERTIES AND FUNCTIONS OF THE NOVEL TYPE I INTERFERON EPSILON. Semin Immunol. 2019; 43:101328. DOI: 10.1016/j.smim.2019.101328. View

14.

Wambier C, Goren A . Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is likely to be androgen mediated. J Am Acad Dermatol. 2020; 83(1):308-309. PMC: 7151476. DOI: 10.1016/j.jaad.2020.04.032. View

15.

Pesu M, Muul L, Kanno Y, OShea J . Proprotein convertase furin is preferentially expressed in T helper 1 cells and regulates interferon gamma. Blood. 2006; 108(3):983-5. PMC: 1895858. DOI: 10.1182/blood-2005-09-3824. View

16.

Choo S, Rayko M, Tan T, Hari R, Komissarov A, Wee W . Pangolin genomes and the evolution of mammalian scales and immunity. Genome Res. 2016; 26(10):1312-1322. PMC: 5052048. DOI: 10.1101/gr.203521.115. View

17.

Estebanez A, Perez-Santiago L, Silva E, Guillen-Climent S, Garcia-Vazquez A, Ramon M . Cutaneous manifestations in COVID-19: a new contribution. J Eur Acad Dermatol Venereol. 2020; 34(6):e250-e251. PMC: 7262266. DOI: 10.1111/jdv.16474. View