Secondary Syphilis with Eosinophilia Complicated by Severe Jarisch-Herxheimer Reaction

Overview

Journal Case Rep Infect Dis

Publisher Wiley

Specialty Infectious Diseases

Date 2020 Jun 11

PMID 32518698

Authors

Anthony Elias

Kirsty Wark

Dana Slape

David Cook

Kenneth Lee

Genevieve McKew

Affiliations

Soon will be listed here.

Abstract

It has long been acknowledged that syphilis is a disease with a diverse range of presentations. We herein describe a case of a young man who presented with fever, rash, and eosinophilia following the commencement of allopurinol, only to be diagnosed with secondary syphilis on histopathology. His treatment was complicated by a severe exacerbation of his cutaneous eruption following the commencement of penicillin, likely secondary to a Jarisch-Herxheimer reaction, an entity often overlooked by clinicians managing syphilis.

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