Emerging Nano/Micro-Structured Degradable Polymeric Meshes for Pelvic Floor Reconstruction

Overview

Journal Nanomaterials (Basel)

Date 2020 Jun 11

PMID 32517067

Citations 8

Authors

Kallyanashis Paul

Saeedeh Darzi

Jerome A Werkmeister

Caroline E Gargett

Shayanti Mukherjee

Affiliations

Soon will be listed here.

Abstract

Pelvic organ prolapse (POP) is a hidden women's health disorder that impacts 1 in 4 women across all age groups. Surgical intervention has been the only treatment option, often involving non-degradable meshes, with variable results. However, recent reports have highlighted the adverse effects of meshes in the long term, which involve unacceptable rates of erosion, chronic infection and severe pain related to mesh shrinkage. Therefore, there is an urgent unmet need to fabricate of new class of biocompatible meshes for the treatment of POP. This review focuses on the causes for the downfall of commercial meshes, and discusses the use of emerging technologies such as electrospinning and 3D printing to design new meshes. Furthermore, we discuss the impact and advantage of nano-/microstructured alternative meshes over commercial meshes with respect to their tissue integration performance. Considering the key challenges of current meshes, we discuss the potential of cell-based tissue engineering strategies to augment the new class of meshes to improve biocompatibility and immunomodulation. Finally, this review highlights the future direction in designing the new class of mesh to overcome the hurdles of foreign body rejection faced by the traditional meshes, in order to have safe and effective treatment for women in the long term.

Citing Articles

Sacrocolpopexy: Alternatives to Mesh Grafts.

Yong C, Raoofi M, Carey M Int Urogynecol J. 2024; 36(1):3-10.

PMID: 39476292 DOI: 10.1007/s00192-024-05956-4.

Puerarin-Loaded Electrospun Patches with Anti-Inflammatory and Pro-Collagen Synthesis Properties for Pelvic Floor Reconstruction.

Zhang D, Xu D, Huang X, Wei Y, Tang F, Qin X Adv Sci (Weinh). 2024; 11(21):e2308590.

PMID: 38509840 PMC: 11151014. DOI: 10.1002/advs.202308590.

Transperineal pelvic floor ultrasound for assessing posterior pelvic injury and prolapse in postpartum women.

Deng S, Jiang Q, Zhu W, Wang M, Zhang Y Am J Transl Res. 2023; 15(10):6170-6179.

PMID: 37969208 PMC: 10641346.

The Role of Three-dimensional Printed Models in Women's Health.

AlRawi A, Basha T, Elmeligy A, Mousa N, Mohammed G Womens Health (Lond). 2023; 19:17455057231199040.

PMID: 37688305 PMC: 10493061. DOI: 10.1177/17455057231199040.

Supramolecular Fibrous Hydrogel Augmentation of Uterosacral Ligament Suspension for Treatment of Pelvic Organ Prolapse.

Miller B, Wolfe W, Gentry J, Grewal M, Highley C, De Vita R Adv Healthc Mater. 2023; 12(22):e2300086.

PMID: 37220996 PMC: 11468651. DOI: 10.1002/adhm.202300086.

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