Article: Histiocyte-rich rhabdomyoblastic tumor: a report of two cases and a review of the differential diagnoses

Histiocyte-rich rhabdomyoblastic tumor is a recently described skeletal muscle neoplasm of uncertain malignant potential, characterized by slow growth, a fibrous capsule containing peripheral lymphoid aggregates, spindle-to-epithelioid cells with a rhabdomyoblastic immunophenotype, and a dense histiocytic infiltrate. It most commonly arises within the muscles of the lower legs and trunk in young-to-middle-aged men, and initial reports suggest indolent behavior. In this paper, we present two additional cases of histiocyte-rich rhabdomyoblastic tumor with similar clinicopathologic features and discuss the differential diagnosis including its overlap with inflammatory leiomyosarcoma.

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References

1.

Martinez A, Fritchie K, Weiss S, Agaimy A, Haller F, Huang H . Histiocyte-rich rhabdomyoblastic tumor: rhabdomyosarcoma, rhabdomyoma, or rhabdomyoblastic tumor of uncertain malignant potential? A histologically distinctive rhabdomyoblastic tumor in search of a place in the classification of skeletal muscle.... Mod Pathol. 2018; 32(3):446-457. DOI: 10.1038/s41379-018-0145-0. View

2.

Cavazzana A, Schmidt D, Ninfo V, Harms D, Tollot M, Carli M . Spindle cell rhabdomyosarcoma. A prognostically favorable variant of rhabdomyosarcoma. Am J Surg Pathol. 1992; 16(3):229-35. DOI: 10.1097/00000478-199203000-00002. View

3.

Mentzel T, Kuhnen C . Spindle cell rhabdomyosarcoma in adults: clinicopathological and immunohistochemical analysis of seven new cases. Virchows Arch. 2006; 449(5):554-60. DOI: 10.1007/s00428-006-0284-4. View

4.

Housley Smith M, Atherton D, Reith J, Islam N, Bhattacharyya I, Cohen D . Rhabdomyosarcoma, Spindle Cell/Sclerosing Variant: A Clinical and Histopathological Examination of this Rare Variant with Three New Cases from the Oral Cavity. Head Neck Pathol. 2017; 11(4):494-500. PMC: 5677073. DOI: 10.1007/s12105-017-0818-x. View

5.

Ferrari A, Dileo P, Casanova M, Bertulli R, Meazza C, Gandola L . Rhabdomyosarcoma in adults. A retrospective analysis of 171 patients treated at a single institution. Cancer. 2003; 98(3):571-80. DOI: 10.1002/cncr.11550. View

6.

Turner J, Richmon J . Head and neck rhabdomyosarcoma: a critical analysis of population-based incidence and survival data. Otolaryngol Head Neck Surg. 2011; 145(6):967-73. DOI: 10.1177/0194599811417063. View

7.

Folpe A, McKenney J, Bridge J, Weiss S . Sclerosing rhabdomyosarcoma in adults: report of four cases of a hyalinizing, matrix-rich variant of rhabdomyosarcoma that may be confused with osteosarcoma, chondrosarcoma, or angiosarcoma. Am J Surg Pathol. 2002; 26(9):1175-83. DOI: 10.1097/00000478-200209000-00008. View

8.

Mentzel T, Katenkamp D . Sclerosing, pseudovascular rhabdomyosarcoma in adults. Clinicopathological and immunohistochemical analysis of three cases. Virchows Arch. 2000; 436(4):305-11. DOI: 10.1007/s004280050451. View

9.

Cheah A, Zou Y, Lanigan C, Billings S, Rubin B, Hornick J . ALK Expression in Angiomatoid Fibrous Histiocytoma: A Potential Diagnostic Pitfall. Am J Surg Pathol. 2018; 43(1):93-101. DOI: 10.1097/PAS.0000000000001103. View

10.

Arbajian E, Koster J, Vult von Steyern F, Mertens F . Inflammatory leiomyosarcoma is a distinct tumor characterized by near-haploidization, few somatic mutations, and a primitive myogenic gene expression signature. Mod Pathol. 2017; 31(1):93-100. DOI: 10.1038/modpathol.2017.113. View

Histiocyte-rich Rhabdomyoblastic Tumor: a Report of Two Cases and a Review of the Differential Diagnoses