Differential Expression Profiles of CircRNAs in Human Prostate Cancer Based on Chip and Bioinformatic Analysis

Overview

Journal Int J Clin Exp Pathol

Specialty Pathology

Date 2020 Jun 9

PMID 32509077

Citations 8

Authors

Shengyang Ge

Chuanyu Sun

Qingfeng Hu

Yijun Guo

Guowei Xia

Yuanyuan Mi

Lijie Zhu

Affiliations

Soon will be listed here.

Abstract

Background: Increasing evidence suggests that circRNAs are involved in the pathogenesis of multiple kinds of cancer. Nevertheless, the differential expression of circRNAs in prostate cancer (PCA) is rarely reported.

Material/method: In our present analyses, circRNAs expression profiles were identified in PCA, based on 5 pairs of PCA and matched non-PCA tissues using circRNA chips.

Results: A number of 749 differential circRNAs were expressed between PCA tumor and paracancerous tissues (Fold Change, FC ≥ 2.0 and < 0.05): 261 were upregulated, whereas 487 were downregulated in PCA tissues. Gene ontology and KEGG pathway analyses indicated that many of the circRNAs are related to carcinogenesis. Circ_0033074 and circ_0016064 both showed changes of maximum magnitude among differentially expressed circRNAs.

Conclusions: Our study detected a relative comprehensive differential map of circRNAs in PCA, which may become novel biomarkers for diagnosis, treatment and follow-up in the future.

Citing Articles

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Circ_0004087 interaction with SND1 promotes docetaxel resistance in prostate cancer by boosting the mitosis error correction mechanism.

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