Subjective Cognitive Decline and Related Cognitive Deficits

Overview

Journal Front Neurol

Specialty Neurology

Date 2020 Jun 9

PMID 32508729

Citations 37

Authors

Tong Si

Guoqiang Xing

Ying Han

Affiliations

Soon will be listed here.

Abstract

Since late stage dementia, including Alzheimer's disease (AD), cannot be reversed by any available drugs, there is increasing research interest in the preclinical stage of AD, i.e., subjective cognitive decline (SCD). SCD is characterized by self-perceptive cognitive decline but is difficult to detect using objective tests. At SCD stage, the cognitive deficits can be more easily reversed compared to that of mild cognitive impairment (MCI) and AD only if accurate diagnosis of SCD and early intervention can be developed. In this paper, we review the recent progress of SCD research including current assessment tools, biomarkers, neuroimaging, intervention and expected prognosis, and the potential relevance to traumatic brain injury (TBI)-induced cognitive deficits.

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References

Lazarou I, Nikolopoulos S, Dimitriadis S, Kompatsiaris I, Spilioti M, Tsolaki M . Is brain connectome research the future frontier for subjective cognitive decline? A systematic review. Clin Neurophysiol. 2019; 130(10):1762-1780. DOI: 10.1016/j.clinph.2019.07.004. View

Jessen F, Wiese B, Bachmann C, Eifflaender-Gorfer S, Haller F, Kolsch H . Prediction of dementia by subjective memory impairment: effects of severity and temporal association with cognitive impairment. Arch Gen Psychiatry. 2010; 67(4):414-22. DOI: 10.1001/archgenpsychiatry.2010.30. View

Roehr S, Riedel-Heller S, Kaduszkiewicz H, Wagner M, Fuchs A, van der Leeden C . Is function in instrumental activities of daily living a useful feature in predicting Alzheimer's disease dementia in subjective cognitive decline?. Int J Geriatr Psychiatry. 2018; 34(1):193-203. DOI: 10.1002/gps.5010. View

Jonker C, Launer L, Hooijer C, Lindeboom J . Memory complaints and memory impairment in older individuals. J Am Geriatr Soc. 1996; 44(1):44-9. DOI: 10.1111/j.1532-5415.1996.tb05636.x. View

Bhome R, Berry A, Huntley J, Howard R . Interventions for subjective cognitive decline: systematic review and meta-analysis. BMJ Open. 2018; 8(7):e021610. PMC: 6059327. DOI: 10.1136/bmjopen-2018-021610. View

Scheef L, Spottke A, Daerr M, Joe A, Striepens N, Kolsch H . Glucose metabolism, gray matter structure, and memory decline in subjective memory impairment. Neurology. 2012; 79(13):1332-9. DOI: 10.1212/WNL.0b013e31826c1a8d. View

Hay J, Johnson V, Young A, Smith D, Stewart W . Blood-Brain Barrier Disruption Is an Early Event That May Persist for Many Years After Traumatic Brain Injury in Humans. J Neuropathol Exp Neurol. 2015; 74(12):1147-57. PMC: 8744142. DOI: 10.1097/NEN.0000000000000261. View

Jia L, Qiu Q, Zhang H, Chu L, Du Y, Zhang J . Concordance between the assessment of Aβ42, T-tau, and P-T181-tau in peripheral blood neuronal-derived exosomes and cerebrospinal fluid. Alzheimers Dement. 2019; 15(8):1071-1080. DOI: 10.1016/j.jalz.2019.05.002. View

Wang X, Zeng Y, Chen G, Zhang Y, Li X, Hao X . Abnormal organization of white matter networks in patients with subjective cognitive decline and mild cognitive impairment. Oncotarget. 2016; 7(31):48953-48962. PMC: 5226483. DOI: 10.18632/oncotarget.10601. View

10.

Amieva H, Le Goff M, Millet X, Orgogozo J, Peres K, Barberger-Gateau P . Prodromal Alzheimer's disease: successive emergence of the clinical symptoms. Ann Neurol. 2008; 64(5):492-8. DOI: 10.1002/ana.21509. View

11.

Clark C, Pontecorvo M, Beach T, Bedell B, Coleman R, Doraiswamy P . Cerebral PET with florbetapir compared with neuropathology at autopsy for detection of neuritic amyloid-β plaques: a prospective cohort study. Lancet Neurol. 2012; 11(8):669-78. DOI: 10.1016/S1474-4422(12)70142-4. View

12.

Wolfsgruber S, Polcher A, Koppara A, Kleineidam L, Frolich L, Peters O . Cerebrospinal Fluid Biomarkers and Clinical Progression in Patients with Subjective Cognitive Decline and Mild Cognitive Impairment. J Alzheimers Dis. 2017; 58(3):939-950. DOI: 10.3233/JAD-161252. View

13.

Amariglio R, Becker J, Carmasin J, Wadsworth L, Lorius N, Sullivan C . Subjective cognitive complaints and amyloid burden in cognitively normal older individuals. Neuropsychologia. 2012; 50(12):2880-2886. PMC: 3473106. DOI: 10.1016/j.neuropsychologia.2012.08.011. View

14.

Studart Neto A, Nitrini R . Subjective cognitive decline: The first clinical manifestation of Alzheimer's disease?. Dement Neuropsychol. 2017; 10(3):170-177. PMC: 5642412. DOI: 10.1590/S1980-5764-2016DN1003002. View

15.

Jessen F, Amariglio R, van Boxtel M, Breteler M, Ceccaldi M, Chetelat G . A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease. Alzheimers Dement. 2014; 10(6):844-52. PMC: 4317324. DOI: 10.1016/j.jalz.2014.01.001. View

16.

Perrotin A, de Flores R, Lamberton F, Poisnel G, La Joie R, De La Sayette V . Hippocampal Subfield Volumetry and 3D Surface Mapping in Subjective Cognitive Decline. J Alzheimers Dis. 2015; 48 Suppl 1:S141-50. DOI: 10.3233/JAD-150087. View

17.

Sierra-Rio A, Balasa M, Olives J, Antonell A, Iranzo A, Castellvi M . Cerebrospinal Fluid Biomarkers Predict Clinical Evolution in Patients with Subjective Cognitive Decline and Mild Cognitive Impairment. Neurodegener Dis. 2015; 16(1-2):69-76. DOI: 10.1159/000439258. View

18.

Eckerstrom M, Skoogh J, Rolstad S, Gothlin M, Steineck G, Johansson B . Sahlgrenska Academy Self-reported Cognitive Impairment Questionnaire (SASCI-Q)--a research tool discriminating between subjectively cognitively impaired patients and healthy controls. Int Psychogeriatr. 2012; 25(3):420-30. DOI: 10.1017/S1041610212001846. View

19.

Vogel A, Salem L, Andersen B, Waldemar G . Differences in quantitative methods for measuring subjective cognitive decline - results from a prospective memory clinic study. Int Psychogeriatr. 2016; 28(9):1513-20. DOI: 10.1017/S1041610216000272. View

20.

Bessi V, Mazzeo S, Padiglioni S, Piccini C, Nacmias B, Sorbi S . From Subjective Cognitive Decline to Alzheimer's Disease: The Predictive Role of Neuropsychological Assessment, Personality Traits, and Cognitive Reserve. A 7-Year Follow-Up Study. J Alzheimers Dis. 2018; 63(4):1523-1535. DOI: 10.3233/JAD-171180. View