Oxidative Stress Pathways of Air Pollution Mediated Toxicity: Recent Insights

Overview

Journal Redox Biol

Specialties Biology
Cell Biology
Endocrinology

Date 2020 Jun 8

PMID 32505541

Citations 84

Authors

Roopesh Singh Gangwar

Graham H Bevan

Rengasamy Palanivel

Lopa Das

Sanjay Rajagopalan

Affiliations

Soon will be listed here.

Abstract

Ambient air pollution is a leading environmental cause of morbidity and mortality globally with most of the outcomes of cardiovascular origin. While numerous mechanisms are proposed to explain the link between air pollutants and cardiovascular events, the evidence supports a role for oxidative stress as a critical intermediary pathway in the transduction of systemic responses in the cardiovascular system. Indeed, alterations in vascular function are a critical step in the development of cardiometabolic disorders such as hypertension, diabetes, and atherosclerosis. This review will provide an overview of the impact of particulate and gaseous pollutants on oxidative stress from human and animal studies published in the last five years. We discuss current gaps in knowledge and evidence to date implicating the role of oxidative stress with an emphasis on inhalational exposures. We conclude with the identification of gaps, and an exhortation for further studies to elucidate the impact of oxidative stress in air pollution mediated effects.

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