Rosai-Dorfman Disease: A Rare Clinicopathological Presentation and Review of the Literature

Overview

Journal Head Neck Pathol

Specialties Oncology
Pathology

Date 2020 Jun 7

PMID 32504287

Citations 7

Authors

Aileen Azari-Yaam

Mohammad Reza Abdolsalehi

Mohammad Vasei

Moeinadin Safavi

Mehrzad Mehdizadeh

Affiliations

Soon will be listed here.

Abstract

Rosai-Dorfman disease (RDD) is a rare and self-limiting disease process that presents most commonly in young patients as massive, painless, cervical lymphadenopathy. Extranodal involvement may also occur. Histopathologic evaluation is the main diagnostic modality. We report an unusual presentation of RDD with cervical lymphadenopathy and an incidentally discovered sinonasal mass, clinically worrisome for malignancy. We emphasize that a high index of clinical suspicion is critical for accurate diagnosis of RDD. Clinicians and pathologists should consider RDD in a differential diagnosis of cervical lymphadenopathy, especially in young patients.

Citing Articles

Hypofractionated Radiation Therapy for Subcutaneous Rosai-Dorfman Disease: A Case Report.

Guenzel R, Breen W, Go R, Feldman A, Lester S Adv Radiat Oncol. 2025; 10(3):101710.

PMID: 39897384 PMC: 11786799. DOI: 10.1016/j.adro.2024.101710.

Case report: Pediatric intraventricular Rosai-Dorfman disease: clinical insights and surgical strategies in a decade-long observational study and literature review.

Liu D, Li N, Zhu Y, Zhong Y, Deng G, Wang M Front Oncol. 2024; 14:1487835.

PMID: 39678509 PMC: 11638206. DOI: 10.3389/fonc.2024.1487835.

Color Doppler Aliasing: Unmasking the Diagnosis of Cardiac Rosai-Dorfman.

Shirvani D, Kim J, Lam J, Tsang M, Yeung D, Price J CASE (Phila). 2024; 8(7):376-380.

PMID: 39221021 PMC: 11364879. DOI: 10.1016/j.case.2024.04.007.

[Infraglottic portion Rosai-Dorfman disease: a case report].

Hu C, Gao F, Zhang Y, Guo B Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2024; 38(8):755-757.

PMID: 39118518 PMC: 11612748. DOI: 10.13201/j.issn.2096-7993.2024.08.016.

Rosai-Dorfmann Disease: A Rare Disease Presenting as a Unilateral Neck Swelling.

John S, Goel T Indian J Otolaryngol Head Neck Surg. 2024; 76(1):1260-1263.

PMID: 38440436 PMC: 10908954. DOI: 10.1007/s12070-023-04254-7.

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