Adenocarcinomatous-predominant Subtype Associated with a Better Prognosis in Adenosquamous Lung Carcinoma

Overview

Journal BMC Cancer

Publisher Biomed Central

Specialty Oncology

Date 2020 Jun 7

PMID 32503451

Citations 6

Authors

Yangli Liu

Ying Zhu

Lihong Bai

Fengjia Chen

Jue Wang

Yubiao Guo

Affiliations

Soon will be listed here.

Abstract

Background: According to the proportion of glandular and squamous pathological components, adenosquamous carcinoma (ASC) could be divided into adenocarcinoma (AC) and squamous cell carcinoma (SCC) predominant subtypes. Due to its rarity, no study investigating the impact of different subtypes on the clinical features, radiologic findings and prognosis characteristics of ASC has been reported.

Methods: Sixty eight patients who underwent surgical resection for lung adenosquamous carcinoma in our institute between January 2006 and March 2017 were retrospectively reviewed. Data regarding the clinical features, radiologic findings and prognosis characteristics were collected.

Results: Thirty nine patients of the study cohort were with AC-predominant ASC and 29 with SCC-predominant ASC. There was no significant difference between the two subgroups in age, gender, smoking history, serum carcinoembryonic antigen (CEA) level and T,N classification. Air bronchogram was found more frequently in AC-predominant ASC than in SCC-predominant ASC (P = 0.046). Multivariate analysis identified pathological subtype (P = 0.022) and CT findings of peripheral location (P = 0.009) to be independent prognostic factors.

Conclusions: AC-predominant ASC were more commonly presented with air bronchogram, and were with a better prognosis than SCC-predominant ASC.

Citing Articles

Adenosquamous Carcinoma of the Lung: Survival, Radiologic Findings, PD-L1, and Driver Mutations.

Illini O, Fabikan H, Fischer E, Lang-Stoberl A, Krenbek D, Jarius C J Clin Med. 2024; 13(19).

PMID: 39407771 PMC: 11476650. DOI: 10.3390/jcm13195711.

Effective neoadjuvant immunotherapy and chemotherapy in stage IIIA adenosquamous carcinoma of the lung with a complete response and surgical success: A case report.

Song C, Nie Y, Liu T, Peng X, Liu J, Zhou Z Oncol Lett. 2024; 28(1):314.

PMID: 38807664 PMC: 11130605. DOI: 10.3892/ol.2024.14448.

Metastatic pattern and prognosis in patients with lung adenosquamous carcinoma: A surveillance, epidemiology, and end results-based population study.

Xie J, Li C Heliyon. 2024; 10(9):e30641.

PMID: 38765098 PMC: 11098840. DOI: 10.1016/j.heliyon.2024.e30641.

Comprehensive analysis of clinicopathological profiles in adenosquamous carcinoma of the lung.

Wang Y, Guo H, Hou L, Wu Y, Li X, Zhao C Am J Transl Res. 2024; 16(1):126-135.

PMID: 38322563 PMC: 10839401.

Distant organ metastasis patterns and prognosis of lung adenosquamous carcinoma: a SEER database analysis.

Xing H, Wu C, Zhang D, Zhang X Interdiscip Cardiovasc Thorac Surg. 2024; 38(2).

PMID: 38216548 PMC: 10838212. DOI: 10.1093/icvts/ivae007.

References

Bastide K, Ugolin N, Levalois C, Bernaudin J, Chevillard S . Are adenosquamous lung carcinomas a simple mix of adenocarcinomas and squamous cell carcinomas, or more complex at the molecular level?. Lung Cancer. 2009; 68(1):1-9. DOI: 10.1016/j.lungcan.2009.11.001. View

Nakagawa K, Yasumitu T, Fukuhara K, Shiono H, Kikui M . Poor prognosis after lung resection for patients with adenosquamous carcinoma of the lung. Ann Thorac Surg. 2003; 75(6):1740-4. DOI: 10.1016/s0003-4975(03)00022-5. View

Gawrychowski J, Brulinski K, Malinowski E, Papla B . Prognosis and survival after radical resection of primary adenosquamous lung carcinoma. Eur J Cardiothorac Surg. 2005; 27(4):686-92. DOI: 10.1016/j.ejcts.2004.12.030. View

Qiang J, Zhou K, Lu G, Wang Q, Ye X, Xu S . The relationship between solitary pulmonary nodules and bronchi: multi-slice CT-pathological correlation. Clin Radiol. 2004; 59(12):1121-7. DOI: 10.1016/j.crad.2004.02.018. View

Lin G, Li C, Li P, Fang W, Xu H, Gong Y . Genomic origin and EGFR-TKI treatments of pulmonary adenosquamous carcinoma. Ann Oncol. 2020; 31(4):517-524. DOI: 10.1016/j.annonc.2020.01.014. View

Kanazawa H, Ebina M, Shimizukawa M, Takahashi T, Fujimura S, Imai T . Transition from squamous cell carcinoma to adenocarcinoma in adenosquamous carcinoma of the lung. Am J Pathol. 2000; 156(4):1289-98. PMC: 1876884. DOI: 10.1016/S0002-9440(10)64999-1. View

Naunheim K, Taylor J, Skosey C, Hoffman P, Ferguson M, Golomb H . Adenosquamous lung carcinoma: clinical characteristics, treatment, and prognosis. Ann Thorac Surg. 1987; 44(5):462-6. DOI: 10.1016/s0003-4975(10)62102-9. View

Maeda H, Matsumura A, Kawabata T, Suito T, Kawashima O, Watanabe T . Adenosquamous carcinoma of the lung: surgical results as compared with squamous cell and adenocarcinoma cases. Eur J Cardiothorac Surg. 2011; 41(2):357-61. DOI: 10.1016/j.ejcts.2011.05.050. View

Lee Y, Chung J, Kim S, Kim T, Lee K . Adenosquamous carcinoma of the lung: CT, FDG PET, and clinicopathologic findings. Clin Nucl Med. 2013; 39(2):107-12. DOI: 10.1097/RLU.0b013e3182952c2d. View

10.

Filosso P, Ruffini E, Asioli S, Giobbe R, Macri L, Bruna M . Adenosquamous lung carcinomas: a histologic subtype with poor prognosis. Lung Cancer. 2011; 74(1):25-9. DOI: 10.1016/j.lungcan.2011.01.030. View

11.

Takamori S, Noguchi M, Morinaga S, Goya T, Tsugane S, Kakegawa T . Clinicopathologic characteristics of adenosquamous carcinoma of the lung. Cancer. 1991; 67(3):649-54. DOI: 10.1002/1097-0142(19910201)67:3<649::aid-cncr2820670321>3.0.co;2-b. View

12.

Travis W, Brambilla E, Nicholson A, Yatabe Y, Austin J, Beasley M . The 2015 World Health Organization Classification of Lung Tumors: Impact of Genetic, Clinical and Radiologic Advances Since the 2004 Classification. J Thorac Oncol. 2015; 10(9):1243-1260. DOI: 10.1097/JTO.0000000000000630. View

13.

Shimizu J, Oda M, Hayashi Y, Nonomura A, Watanabe Y . A clinicopathologic study of resected cases of adenosquamous carcinoma of the lung. Chest. 1996; 109(4):989-94. DOI: 10.1378/chest.109.4.989. View

14.

Li C, Lu H . Adenosquamous carcinoma of the lung. Onco Targets Ther. 2018; 11:4829-4835. PMC: 6098426. DOI: 10.2147/OTT.S164574. View

15.

Watanabe Y, Tsuta K, Kusumoto M, Yoshida A, Suzuki K, Asamura H . Clinicopathologic features and computed tomographic findings of 52 surgically resected adenosquamous carcinomas of the lung. Ann Thorac Surg. 2013; 97(1):245-51. DOI: 10.1016/j.athoracsur.2013.09.018. View

16.

Wang R, Pan Y, Li C, Zhang H, Garfield D, Li Y . Analysis of major known driver mutations and prognosis in resected adenosquamous lung carcinomas. J Thorac Oncol. 2014; 9(6):760-8. DOI: 10.1097/JTO.0b013e3182a406d1. View

17.

Niho S, Yokose T, Kodama T, Nishiwaki Y, Mukai K . Clonal analysis of adenosquamous carcinoma of the lung. Jpn J Cancer Res. 2000; 90(11):1244-7. PMC: 5926013. DOI: 10.1111/j.1349-7006.1999.tb00703.x. View

18.

Zhang Y, Qiang J, Shen Y, Ye J, Zhang J, Zhu L . Using air bronchograms on multi-detector CT to predict the invasiveness of small lung adenocarcinoma. Eur J Radiol. 2016; 85(3):571-7. DOI: 10.1016/j.ejrad.2015.12.014. View

19.

Shiozawa T, Ishii G, Goto K, Nagai K, Mimaki S, Ono S . Clinicopathological characteristics of EGFR mutated adenosquamous carcinoma of the lung. Pathol Int. 2013; 63(2):77-84. DOI: 10.1111/pin.12033. View

20.

Mordant P, Grand B, Cazes A, Foucault C, Dujon A, Le Pimpec Barthes F . Adenosquamous carcinoma of the lung: surgical management, pathologic characteristics, and prognostic implications. Ann Thorac Surg. 2013; 95(4):1189-95. DOI: 10.1016/j.athoracsur.2012.12.037. View