Phylogenomic Characterisation of a Novel Corynebacterial Species Pathogenic to Animals

Overview

Journal Antonie Van Leeuwenhoek

Publisher Springer

Specialty Microbiology

Date 2020 Jun 6

PMID 32500295

Citations 9

Authors

Jens Moller

Luca Musella

Vyacheslav Melnikov

Walter Geissdorfer

Andreas Burkovski

Vartul Sangal

Affiliations

Soon will be listed here.

Abstract

The genus Corynebacterium includes species of biotechnological, medical and veterinary importance. An atypical C. ulcerans strain, W25, was recently isolated from a case of necrotizing lymphadenitis in a wild boar. In this study, we have analysed the genome sequence of this strain and compared the phenotypic and virulence properties with other corynebacterial pathogens. Phylogenomic analyses revealed that strain W25 belongs to a novel species along with PO100/5 and KL1196. The latter strains were isolated from a pig and a roe deer, respectively; hence, this species appears to be associated to animals. The isolate W25 is likely a non-toxigenic tox gene bearing strain and may have compromised abilities to adhere to pharyngeal and laryngeal epithelial cells due to potential loss of the gene functions in spaBC and spaDEF pilus gene clusters. A number of corynebacterial virulence genes are present including pld encoding phospholipase D. Therefore, this strain may be able to cause severe invasive infections in animals and zoonotic infections in humans.

Citing Articles

First Report of Caseous Lymphadenitis by and Pulmonary Verminosis in a Roe Deer ( Linnaeus, 1758) in Italy.

Di Donato A, Gambi L, Ravaioli V, Perulli S, Cirasella L, Rossini R Animals (Basel). 2024; 14(4).

PMID: 38396534 PMC: 10885920. DOI: 10.3390/ani14040566.

Proteomics of Toxigenic Corynebacteria.

Burkovski A Proteomes. 2024; 12(1).

PMID: 38250813 PMC: 10801583. DOI: 10.3390/proteomes12010002.

Analysis of genomes from Portugal reveals a single cluster and a clade suggested to produce diphtheria toxin.

Viana M, Galdino J, Profeta R, Oliveira M, Tavares L, de Castro Soares S PeerJ. 2023; 11:e14895.

PMID: 36919166 PMC: 10008321. DOI: 10.7717/peerj.14895.

Multi-Omics of 12CS0282 and an In Silico Reverse Vaccinology Approach Reveal Novel Vaccine and Drug Targets.

Moller J, Bodenschatz M, Sangal V, Hofmann J, Burkovski A Proteomes. 2022; 10(4).

PMID: 36548458 PMC: 9784263. DOI: 10.3390/proteomes10040039.

New Species with the Potential to Produce Diphtheria Toxin.

Prygiel M, Polak M, Mosiej E, Wdowiak K, Forminska K, Zasada A Pathogens. 2022; 11(11).

PMID: 36365015 PMC: 9693595. DOI: 10.3390/pathogens11111264.

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