The Association Between Anthropometric Parameters and Cardiovascular Risk Indicators in Women with Polycystic Ovarian Syndrome

Overview

Journal ARYA Atheroscler

Date 2020 Jun 6

PMID 32499830

Citations 2

Authors

Ahmad Mirdamadi

Soheila Riahinejad

Samane Varnaseri

Affiliations

Soon will be listed here.

Abstract

Background: In patients with polycystic ovarian syndrome (PCOS), this is now hypothesized that whether increased risk for cardiovascular disorders is related more to obesity than PCOS per se. This study aimed to compare cardiovascular risk factors between the lean and obese women with PCOS.

Methods: This case-control study was conducted on 86 (43 obese and 43 lean) women with PCOS. The presence of overweight and obesity was defined based on the body mass index (BMI) (> 25 kg/m2). The study objectives were first to compare mean levels of cardiovascular laboratory parameters between lean and obese patients with PCOS and then to assess the relationship between obesity indices and these laboratory parameters.

Results: Compared to the lean group, the obese group had significantly higher mean fasting blood sugar (FBS) (89.40 ± 10.73 versus 84.09 ± 7.87 mg/dl, P = 0.011), higher mean serum triglyceride (TG) (119.09 ± 60.66 versus 96.86 ± 27.23 mg/dl, P = 0.032), higher mean total cholesterol (147.70 ± 57.38 versus 126.79 ± 35.95 mg/dl, P = 0.045), and also higher mean low-density lipoprotein (LDL) (92.30 ± 13.53 versus 83.77 ± 17.61 mg/dl, P = 0.014). Using the Pearson's correlation test, positive correlations were found between BMI and waist circumference (WC) indices and study parameters including FBS, serum TG, serum total cholesterol, serum LDL, and also blood pressure (BP).

Conclusion: Because of higher concentrations of FBS and lipid profiles in obese patients with PCOS and considering obesity as a more important risk factor for coronary artery disease (CAD) than PCOS, it is recommended to assess and monitor cardiovascular risk factors in these population to reduce the risk for cardiovascular disorders and metabolic syndrome. Also, by reducing body weight and normalizing BMI value, the cardiovascular and metabolic risk factors can be modified and prevented.

Citing Articles

Insulin level, lipid profile, and HOMA index in lean and obese patients with polycystic ovary syndrome.

Hussein S, Sadiq A, Johar S, Nasrawi A J Med Life. 2023; 16(8):1258-1263.

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Protective effects of liquiritin on polycystic ovary syndrome through modulating ovarian granulosa cell proliferation and apoptosis via miR-206/PI3K/AKT pathway.

Cui X, Zhou S, Lin Y Cytotechnology. 2022; 74(3):385-393.

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