Acute Hypersensitivity Pneumonitis Associated With a High Ki-67 Proliferative Index
Overview
Overview
Authors
Affiliations
Affiliations
Soon will be listed here.
Abstract
Hypersensitivity pneumonitis (HSP) is an interstitial lung disease caused by exposure to a large range of environmental antigens. Inhaling aerosolized particles leads to a heightened immune response. HSP comes in acute, subacute, or chronic forms, all with their own potential clinical and radiographic findings. complex (MAC) is the most common nontuberculous mycobacteria and is known to cause HSP with certain exposures. However, although certain histologic findings can be seen with HSP, a high ki-67 proliferation index is unusual and more commonly associated with malignancy. In this report, we discuss a case of MAC that had acute HSP associated with a high ki-67 proliferative index.
References
1.
Koh W, Kwon O, Lee K
. Nontuberculous mycobacterial pulmonary diseases in immunocompetent patients. Korean J Radiol. 2002; 3(3):145-57.
PMC: 2714412.
DOI: 10.3348/kjr.2002.3.3.145.
View
2.
Plantier L, Cazes A, Dinh-Xuan A, Bancal C, Marchand-Adam S, Crestani B
. Physiology of the lung in idiopathic pulmonary fibrosis. Eur Respir Rev. 2018; 27(147).
PMC: 9489199.
DOI: 10.1183/16000617.0062-2017.
View
3.
Marras T, Wallace Jr R, Koth L, Stulbarg M, Cowl C, Daley C
. Hypersensitivity pneumonitis reaction to Mycobacterium avium in household water. Chest. 2005; 127(2):664-71.
DOI: 10.1378/chest.127.2.664.
View
4.
Acs B, Zambo V, Vizkeleti L, Szasz A, Madaras L, Szentmartoni G
. Ki-67 as a controversial predictive and prognostic marker in breast cancer patients treated with neoadjuvant chemotherapy. Diagn Pathol. 2017; 12(1):20.
PMC: 5320658.
DOI: 10.1186/s13000-017-0608-5.
View
5.
Franks T, Galvin J
. Hypersensitivity Pneumonitis: Essential Radiologic and Pathologic Findings. Surg Pathol Clin. 2016; 3(1):187-98.
DOI: 10.1016/j.path.2010.03.005.
View