T-Peak to T-End Improvements After Beta-Blocker Administration in Peripartum Cardiomyopathy Patients

Overview

Journal Cardiol Res

Specialty Cardiology & Vascular Diseases

Date 2020 Jun 5

PMID 32494328

Citations 2

Authors

Chaerul Achmad

Mohammad Iqbal

Giky Karwiky

Hawani Sasmaya Prameswari

Mega Febrianora

Affiliations

Soon will be listed here.

Abstract

Background: Many studies have shown that T-peak to T-end (TPTE) interval was associated with sudden cardiac events. Peripartum cardiomyopathy (PPCM) causes reversible left ventricle systolic dysfunction which may deteriorate into sudden cardiac death. This study aimed to evaluate beta-blocker as an antiarrhythmic agent to improve TPTE interval as a prognostic value of sudden cardiac death.

Methods: A cohort experimental prospective study was performed. The PPCM was diagnosed from the emergency ward. A total of 54 cases were identified from 2014 to 2016. Thirty-four patients were followed up for further analysis. Electrocardiograms were conducted in all the patients, and TPTE interval was measured. After a follow-up of 6 months of beta-blocker treatment, the echocardiography and TPTE interval were measured again to obtain the repolarization heterogeneity.

Results: The mean age of subjects was 32 ± 6.4 years. The mean left ventricular ejection fraction (LVEF) was 32.24±6.3%. The mean TPTE interval was 123.7 ± 28.2 ms. After 6 months of beta-blocker administration, the mean LVEF was 58.26±4.4% and the mean TPTE was 98.7 ± 39.5 ms. The paired -test showed a significant difference between TPTE interval pre- and post-administration of beta-blocker (P value < 0.001).

Conclusions: There is an improvement of TPTE in PPCM patients after 6 months of beta-blocker administration. Administration of beta-blocker in PPCM patients is expected to prevent sudden cardiac death in PPCM populations.

Citing Articles

Tpeak-Tend Interval during Pregnancy and Postpartum.

Kandzia T, Markiewicz-Loskot G, Binkiewicz P Int J Environ Res Public Health. 2022; 19(19).

PMID: 36231942 PMC: 9566342. DOI: 10.3390/ijerph191912638.

Correlation Between T Peak to End Interval and Left Ventricular Time to Peak Longitudinal Strain in Ischemic Cardiomyopathy Patients.

Achmad C, Prianda A, Tiksnadi B, Iqbal M, Karwiky G, Febrianora M Cardiol Res. 2020; 11(5):337-341.

PMID: 32849969 PMC: 7430883. DOI: 10.14740/cr1126.

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