Synchronous Double Bile Duct Cancers with Distinct Genetic Features

Overview

Journal Intern Med

Specialty General Medicine

Date 2020 Jun 5

PMID 32493852

Citations 1

Authors

Shinichi Morita

Takeshi Suda

Yoji Kishi

Toshimitsu Iwasaki

Nobuyoshi Hiraoka

Itsuo Nagayama

Takahiro Hoshi

Satoshi Abe

Kazuyoshi Yagi

Go Hasegawa

Toshihiko Ikarashi

Shuji Terai

Affiliations

Soon will be listed here.

Abstract

A 69-year-old man was referred to our hospital because of appetite loss. Imaging showed a nodular tumor in the perihilar bile duct and a second flat lesion in the distal bile duct. Right hepatopancreaticoduodenectomy was performed, and the histopathological findings demonstrated that the perihilar and distal lesions were moderately and poorly differentiated adenocarcinoma, respectively, and anatomically separated. Furthermore, the resected specimens showed no pancreaticobiliary maljunction. Histological and TP53 gene analyses in a rare case of synchronous double bile duct cancers suggest that there are various genetic pathways through which bile duct cancer develops, highlighting the complexity of its pathogenesis.

Citing Articles

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